Novel Technologies for the External Stimuli-Responsive Control of Cellular Functions, Properties and Fate

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 3990

Special Issue Editors


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Department of Biomedical Engineering, School of Integrative Engineering, College of ICT Engineering, Chung-Ang University, Seoul 06974, Republic of Korea
Interests: nanomedicine; biosensor; theragnostics; drug delivery; nanobiomaterials
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Pillar of Engineering Product Development, Singapore University of Technology and Design, Singapore, Singapore
Interests: microfluidics; bioprinting; organ-on-a-chip; flexible devices; food printing
Special Issues, Collections and Topics in MDPI journals

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Department of Chemical Engineering, University of New Hampshire, Durham, NH 03824, USA
Interests: biomaterials; tissue engineering; drug delivery

Special Issue Information

Dear Colleagues,

Novel technologies are emerging for the external control and engineering of cell functions and properties. Among the many genes and proteins of target cells, the technology to quickly activate them and effectively control the expression of target molecules is critical. Therefore, the requirement for high-throughput screening and analyses of target genes and proteins as well as controlling them in cells externally using electromagnetic, thermal, and optical stimuli has become increasingly relevant. At the same time, the new tools and instruments developed from novel technologies exciting target biomolecules in body or in tissue have also been significantly employed. Achievement of these goals requires a detailed study of gene/protein screening and analyses, external stimuli-responsive material development, cellular function/fate/properties assays, etc. This Special Issue will highlight the current state-of-the-art of high-throughput screening tools for the discovery and characterization of external stimuli responsive genes/proteins, as well as the most up-to-date technologies for the control of cell functions, properties and fate using external stimuli responsive genes/proteins. These methods would also suggest prospects for optimizing methodologies in detailed control and engineering of cells (e.g., ion channel control, differentiation, gene expression). Towards these aims, this Special Issue will compile a series of research articles and review papers dedicated to studying these objectives.

Prof. Jonghoon Choi
Dr. Michinao Hashimoto
Dr. Kyung Jae Jeong
Guest Editors

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Keywords

  • electromagnetic control
  • cell function
  • stimuli-responsive
  • cell properties
  • external cell control

Published Papers (1 paper)

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Research

11 pages, 2300 KiB  
Article
Regulation of Electromagnetic Perceptive Gene Using Ferromagnetic Particles for the External Control of Calcium Ion Transport
by Jangsun Hwang, Yonghyun Choi, Kyungwoo Lee, Vijai Krishnan, Galit Pelled, Assaf A. Gilad and Jonghoon Choi
Biomolecules 2020, 10(2), 308; https://doi.org/10.3390/biom10020308 - 15 Feb 2020
Cited by 13 | Viewed by 3608
Abstract
Developing synthetic biological devices to allow the noninvasive control of cell fate and function, in vivo can potentially revolutionize the field of regenerative medicine. To address this unmet need, we designed an artificial biological “switch” that consists of two parts: (1) the electromagnetic [...] Read more.
Developing synthetic biological devices to allow the noninvasive control of cell fate and function, in vivo can potentially revolutionize the field of regenerative medicine. To address this unmet need, we designed an artificial biological “switch” that consists of two parts: (1) the electromagnetic perceptive gene (EPG) and (2) magnetic particles. Our group has recently cloned the EPG from the Kryptopterus bicirrhis (glass catfish). The EPG gene encodes a putative membrane-associated protein that responds to electromagnetic fields (EMFs). This gene’s primary mechanism of action is to raise the intracellular calcium levels or change in flux through EMF stimulation. Here, we developed a system for the remote regulation of [Ca2+]i (i.e., intracellular calcium ion concentration) using streptavidin-coated ferromagnetic particles (FMPs) under a magnetic field. The results demonstrated that the EPG-FMPs can be used as a molecular calcium switch to express target proteins. This technology has the potential for controlled gene expression, drug delivery, and drug developments. Full article
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