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Special Issue Information

Dear Colleagues,

The use of miniaturized systems confers numerous advantages for monitoring in clinical diagnostics, environmental control, food industry control, and others. This Special Issue will showcase recent advances in microfluidics and lab-on-chip sensing devices for precise processing and analytical detection.

Researchers working in novel microfluidics and/or integrated sensing transducers are welcome to submit original work and reviews that focus on topics including, but not limited to, the following: manufacturing of microfluidics and lab-on-chip; application of (bio)sensing integrated systems; miniaturized (electro)chemical sensors; optical and gas sensors; capacitive sensors; electrochemical sensors; FET sensors; radio frequency sensors; electronic miniaturization for sensing control; miniaturized mechanical sensors; point-of-care devices; point-of-need devices; organ-on-chip; nano-technology; paper-based devices; etc.

Dr. Pablo Giménez-Gómez
Dr. Roberto Pilloton
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

microfluidics
lab-on-chip
(bio)sensing
integrated systems
point-of-care
point-of-need

Published Papers (2 papers)

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Research

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13 pages, 1476 KiB

Open AccessArticle

Switching Separation Migration Order by Switching Electrokinetic Regime in Electrokinetic Microsystems

by Alaleh Vaghef-Koodehi and Blanca H. Lapizco-Encinas

Biosensors 2024, 14(3), 119; https://doi.org/10.3390/bios14030119 - 22 Feb 2024

Cited by 1 | Viewed by 1015

Abstract

Analyte migration order is a major aspect in all migration-based analytical separations methods. Presented here is the manipulation of the migration order of microparticles in an insulator-based electrokinetic separation. Three distinct particle mixtures were studied: a binary mixture of particles with similar electrical charge and different sizes, and two tertiary mixtures of particles of distinct sizes. Each one of the particle mixtures was separated twice, the first separation was performed under low voltage (linear electrokinetic regime) and the second separation was performed under high voltage (nonlinear electrokinetic regime). Linear electrophoresis, which discriminates particles by charge, is the dominant electrokinetic effect in the linear regime; while nonlinear electrophoresis, which discriminates particles by size and shape, is the dominant electrokinetic effect in the nonlinear regime. The separation results obtained with the three particle mixtures illustrated that particle elution order can be changed by switching from the linear electrokinetic regime to the nonlinear electrokinetic regime. Also, in all cases, better separation performances in terms of separation resolution (Rs) were obtained by employing the nonlinear electrokinetic regime allowing nonlinear electrophoresis to be the discriminatory electrokinetic mechanism. These findings could be applied to analyze complex samples containing bioparticles of interest within the micron size range. This is the first report where particle elution order is altered in an iEK system. Full article

(This article belongs to the Special Issue Advanced Microfluidic Devices and Lab-on-Chip (Bio)sensors)

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Review

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24 pages, 5732 KiB

Open AccessReview

Microfluidics in High-Throughput Drug Screening: Organ-on-a-Chip and C. elegans-Based Innovations

by Sunhee Yoon, Dilara Kilicarslan You, Uiechan Jeong, Mina Lee, Eunhye Kim, Tae-Joon Jeon and Sun Min Kim

Biosensors 2024, 14(1), 55; https://doi.org/10.3390/bios14010055 - 21 Jan 2024

Viewed by 2078

Abstract

The development of therapeutic interventions for diseases necessitates a crucial step known as drug screening, wherein potential substances with medicinal properties are rigorously evaluated. This process has undergone a transformative evolution, driven by the imperative need for more efficient, rapid, and high-throughput screening platforms. Among these, microfluidic systems have emerged as the epitome of efficiency, enabling the screening of drug candidates with unprecedented speed and minimal sample consumption. This review paper explores the cutting-edge landscape of microfluidic-based drug screening platforms, with a specific emphasis on two pioneering approaches: organ-on-a-chip and C. elegans-based chips. Organ-on-a-chip technology harnesses human-derived cells to recreate the physiological functions of human organs, offering an invaluable tool for assessing drug efficacy and toxicity. In parallel, C. elegans-based chips, boasting up to 60% genetic homology with humans and a remarkable affinity for microfluidic systems, have proven to be robust models for drug screening. Our comprehensive review endeavors to provide readers with a profound understanding of the fundamental principles, advantages, and challenges associated with these innovative drug screening platforms. We delve into the latest breakthroughs and practical applications in this burgeoning field, illuminating the pivotal role these platforms play in expediting drug discovery and development. Furthermore, we engage in a forward-looking discussion to delineate the future directions and untapped potential inherent in these transformative technologies. Through this review, we aim to contribute to the collective knowledge base in the realm of drug screening, providing valuable insights to researchers, clinicians, and stakeholders alike. We invite readers to embark on a journey into the realm of microfluidic-based drug screening platforms, fostering a deeper appreciation for their significance and promising avenues yet to be explored. Full article

(This article belongs to the Special Issue Advanced Microfluidic Devices and Lab-on-Chip (Bio)sensors)

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