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Biosensors
Special Issues
Biosensing, Biosafety and Diagnosis
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Biosensing, Biosafety and Diagnosis

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (15 September 2024) | Viewed by 5809

Special Issue Editor

Dr. Chenxu Yu

E-Mail Website
Guest Editor
Department of Agricultural and Biosystems Engineering, Iowa State University, Ames, IA, USA
Interests: biosensors; nanotechnology; spectroscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biosensors play pivotal roles in health management, biosafety monitoring and diagnosis of various diseases. Technologies developed for biosensing encompass multidisciplinary research areas, from physics, chemistry and engineering, to medical sciences. Various smart nanomaterial-based probes and machine-learning- (ML) and AI-driven data techniques are utilized in biosensing, alongside advanced device development, including lab-on-a-chip (LOCs) and/or organ-on-a-chip (OOCs), to achieve highly sensitive and selective detection and tracking of biomarkers and biological changes in humans, animals and the environment. This Special Issue, entitled “Biosensing, Biosafety and Diagnosis”, will feature the latest discoveries and innovative approaches that have emerged in the field of biosensing research for health/biosafety monitoring and diagnostics, which will lead to better practice to promote human and animal wellness. The topics covered in this Special Issue will be as follows:

  1. Smart nanomaterial-based sensors for disease-related biomarkers;
  2. Point of care diagnostics;
  3. ML/AI-driven spectroscopic and image processing for diagnostic biosensing;
  4. LOCs and/or OOCs sensors for biological characterization;
  5. Nanosensors for drug delivery and treatment evaluation.

Dr. Chenxu Yu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoprobes
  • lab-on-a-chip
  • organ-on-a-chip
  • machine learning
  • diagnostics
  • biosafety

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

18 pages, 4421 KiB  
Article
Colorimetric Glucose Biosensor Based on Chitosan Films and Its Application for Glucose Detection in Beverages Using a Smartphone Application
by Anastasia Skonta, Myrto G. Bellou, Theodore E. Matikas and Haralambos Stamatis
Biosensors 2024, 14(6), 299; https://doi.org/10.3390/bios14060299 - 7 Jun 2024
Viewed by 1171
Abstract
Nowadays, biosensors are gaining increasing interest in foods’ and beverages’ quality control, owing to their economic production, enhanced sensitivity, specificity, and faster analysis. In particular, colorimetric biosensors can be combined with color recognition applications on smartphones for the detection of analytes, rendering the [...] Read more.
Nowadays, biosensors are gaining increasing interest in foods’ and beverages’ quality control, owing to their economic production, enhanced sensitivity, specificity, and faster analysis. In particular, colorimetric biosensors can be combined with color recognition applications on smartphones for the detection of analytes, rendering the whole procedure more applicable in everyday life. Herein, chitosan (CS) films were prepared with the deep eutectic solvent (DES) choline chloride/urea/glycerol (ChCl:U:Gly). Glucose oxidase (GOx), a widely utilized enzyme in quality control, was immobilized within CS films through glutaraldehyde (GA), leading to the formation of CS/GOx films. The optimized GOx concentration and DES content were determined for the films. Moreover, the effect of the pH and temperature of the glucose oxidation reaction on the enzymatic activity of GOx was studied. The structure, stability, and specificity of the CS/GOx films as well as the Km values of free and immobilized GOx were also determined. Finally, the analytical performance of the films was studied by using both a spectrophotometer and a color recognition application on a smartphone. The results demonstrated that the films were highly accurate, specific to glucose, and stable when stored at 4 °C for 4 weeks and when reused 10 times, without evident activity loss. Furthermore, the films displayed a good linear response range (0.1–0.8 mM) and a good limit of detection (LOD, 33 μM), thus being appropriate for the estimation of glucose concentration in real samples through a smartphone application. Full article
(This article belongs to the Special Issue Biosensing, Biosafety and Diagnosis)
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12 pages, 1003 KiB  
Article
L-Lactate Electrochemical Biosensor Based on an Integrated Supramolecular Architecture of Multiwalled Carbon Nanotubes Functionalized with Avidin and a Recombinant Biotinylated Lactate Oxidase
by Alejandro Tamborelli, Michael López Mujica, Marilla Amaranto, José Luis Barra, Gustavo Rivas, Agustina Godino and Pablo Dalmasso
Biosensors 2024, 14(4), 196; https://doi.org/10.3390/bios14040196 - 16 Apr 2024
Viewed by 1498
Abstract
L-Lactate is an important bioanalyte in the food industry, biotechnology, and human healthcare. In this work, we report the development of a new L-lactate electrochemical biosensor based on the use of multiwalled carbon nanotubes non-covalently functionalized with avidin (MWCNT-Av) deposited at glassy carbon [...] Read more.
L-Lactate is an important bioanalyte in the food industry, biotechnology, and human healthcare. In this work, we report the development of a new L-lactate electrochemical biosensor based on the use of multiwalled carbon nanotubes non-covalently functionalized with avidin (MWCNT-Av) deposited at glassy carbon electrodes (GCEs) as anchoring sites for the bioaffinity-based immobilization of a new recombinant biotinylated lactate oxidase (bLOx) produced in Escherichia coli through in vivo biotinylation. The specific binding of MWCNT-Av to bLOx was characterized by amperometry, surface plasmon resonance (SPR), and electrochemical impedance spectroscopy (EIS). The amperometric detection of L-lactate was performed at −0.100 V, with a linear range between 100 and 700 µM, a detection limit of 33 µM, and a quantification limit of 100 µM. The proposed biosensor (GCE/MWCNT-Av/bLOx) showed a reproducibility of 6.0% and it was successfully used for determining L-lactate in food and enriched serum samples. Full article
(This article belongs to the Special Issue Biosensing, Biosafety and Diagnosis)
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17 pages, 10492 KiB  
Article
Shielded Cone Coil Array for Non-Invasive Deep Brain Magnetic Stimulation
by Rawan Abu Yosef, Kamel Sultan, Ahmed Toaha Mobashsher, Firuz Zare, Paul C. Mills and Amin Abbosh
Biosensors 2024, 14(1), 32; https://doi.org/10.3390/bios14010032 - 9 Jan 2024
Viewed by 2225
Abstract
Non-invasive deep brain stimulation using transcranial magnetic stimulation is a promising technique for treating several neurological disorders, such as Alzheimer’s and Parkinson’s diseases. However, the currently used coils do not demonstrate the required stimulation performance in deep regions of the brain, such as [...] Read more.
Non-invasive deep brain stimulation using transcranial magnetic stimulation is a promising technique for treating several neurological disorders, such as Alzheimer’s and Parkinson’s diseases. However, the currently used coils do not demonstrate the required stimulation performance in deep regions of the brain, such as the hippocampus, due to the rapid decay of the field inside the head. This study proposes an array that uses the cone coil method for deep stimulation. This study investigates the impact of magnetic core and shielding on field strength, focality, decay rate, and safety. The coil’s size and shape effects on the electric field distribution in deep brain areas are also examined. The finite element method is used to calculate the induced electric field in a realistic human head model. The simulation results indicate that the magnetic core and shielding increase the electric field intensity and enhance focality but do not improve the field decay rate. However, the decay rate can be reduced by increasing the coil size at the expense of focality. By adopting an optimum cone structure, the proposed five-coil array reduces the electric field attenuation rate to reach the stimulation threshold in deep regions while keeping all other regions within safety limits. In vitro and in vivo experimental results using a head phantom and a dead pig’s head validate the simulated results and confirm that the proposed design is a reliable and efficient candidate for non-invasive deep brain magnetic stimulation. Full article
(This article belongs to the Special Issue Biosensing, Biosafety and Diagnosis)
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