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Brain Sciences
Special Issues
The Pathophysiology of Sleep Disorders
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The Pathophysiology of Sleep Disorders

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuropharmacology and Neuropathology".

Deadline for manuscript submissions: 25 June 2024 | Viewed by 2044

Special Issue Editors

Dr. Thomas C. Thannickal

E-Mail Website1 Website2
Guest Editor
Department of Psychiatry and Biobehavioural Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA
Interests: sleep; narcolepsy; orexin; hypocretin; neurodegeneration; sleep disorders
Dr. Ramalingam Vetrivelan

E-Mail Website
Guest Editor
Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA
Interests: sleep-wake behavior; REM sleep; neural circuits; thermoregulation; cataplexy; REM behavior disorder

Special Issue Information

Dear Colleagues,

Sleep is a complex biological process for brain and body to perform a number of functions to maintain health. Normal wake and sleep states are generated by a complex neuronal network in the brain and are regulated by homeostatic and circadian mechanisms. The function, biological meaning, and physiological organization of sleep are still pieces of an unresolved scientific puzzle. Sleep disruption can cause multiple disorders. The most common sleep disorders are insomnia, hypersomnia, parasomnia, sleep apnea, restless leg syndrome, and circadian rhythm disorders. Sleep disorders are an undervalued public health problem. Sleep takes up a third of every human being’s life and receives much less attention than it deserves by healthcare professionals and policymakers. This Special Edition on “The Pathophysiology of Sleep Disorders” serves as a wakeup call for the importance of sleep and the fact that studying, assessing, and treating its disorders should receive greater prominence in modern medicine.

Dr. Thomas C. Thannickal
Dr. Ramalingam Vetrivelan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • insomnia
  • hypersomnia
  • parasomnia
  • sleep apnea
  • restless leg syndrome
  • circadian rhythm disorders
  • narcolepsy
  • REM sleep behavior disorder
  • neurodegenerative diseases

Published Papers (1 paper)

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13 pages, 928 KiB  
Systematic Review
Systematic Review on the Link between Sleep Bruxism and Systemic Chronic Inflammation
by Michal Fulek, Mieszko Wieckiewicz, Anna Szymanska-Chabowska, Monika Michalek-Zrabkowska, Katarzyna Fulek, Gabriella Lachowicz, Rafal Poreba, Grzegorz Mazur and Helena Martynowicz
Brain Sci. 2023, 13(7), 1104; https://doi.org/10.3390/brainsci13071104 - 21 Jul 2023
Cited by 1 | Viewed by 1653
Abstract
Sleep bruxism (SB) is a sleep-related behavior characterized as rhythmic (phasic) or non-rhythmic (tonic) masticatory muscle activity. SB is a common sleep behavior with a predominantly central origin. The aim of this systematic review was to evaluate the relationship between inflammatory status and [...] Read more.
Sleep bruxism (SB) is a sleep-related behavior characterized as rhythmic (phasic) or non-rhythmic (tonic) masticatory muscle activity. SB is a common sleep behavior with a predominantly central origin. The aim of this systematic review was to evaluate the relationship between inflammatory status and SB according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 (PRISMA 2020). The research was registered at PROSPERO (CRD42023395985). We performed a systematic literature analysis using five different databases. Furthermore, the backward snowballing technique was applied to identify additional papers. Initially, 28 papers were screened from the database search, and 162 papers were revealed in the backward snowballing process. Eventually, five articles were included. Data concerning the inflammatory status of patients experiencing SB were investigated and summarized. Due to the heterogeneity of the compared studies, only a qualitative comparison and narrative summary were performed. The results suggest that SB could be associated with systemic inflammation. In fact, this systematic review revealed that there are no papers conclusively showing that the inflammatory status in bruxers is comparable to non-bruxers. However, each of the examined studies utilized different methods of assessing systemic inflammation, which makes the results dubious. Full article
(This article belongs to the Special Issue The Pathophysiology of Sleep Disorders)
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