Changes in Cellular Function and Synaptic Transmission in Learning and Memory

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".

Deadline for manuscript submissions: closed (31 December 2018) | Viewed by 5845

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School of Behavioral and Brain Sciences, The University of Texas at Dallas, TX 75080, USA
Interests: prefrontal cortex; schizophrenia; drug addiction; working memory; catecholamines
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The ability to learn, form lasting memories, and use this stored information to guide future behaviour are important adaptive and highly conserved neurobiological processes. Neurons communicate with each other through synapses, and the strength of these connections can be altered to direct the flow of information within the central nervous system. Activity-dependent changes in synaptic connections and alterations in the intrinsic excitability of neurons are cellular key features that support learning and memory. This Special Issue will present and discuss the neural processes that enable memory formation, storage and recall under normal and pathophysiological conditions.

Dr. Sven Kroener
Guest Editor

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Keywords

  • synapse
  • physiology
  • recall
  • consolidation
  • memory storage
  • excitation
  • inhibition

Published Papers (1 paper)

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Review

23 pages, 2766 KiB  
Review
Localization of Free and Bound Metal Species through X-Ray Synchrotron Fluorescence Microscopy in the Rodent Brain and Their Relation to Behavior
by Caroline L. C. Neely, Stephen L. P. Lippi, Antonio Lanzirotti and Jane M. Flinn
Brain Sci. 2019, 9(4), 74; https://doi.org/10.3390/brainsci9040074 - 28 Mar 2019
Cited by 13 | Viewed by 5535
Abstract
Biometals in the brain, such as zinc, copper, and iron, are often discussed in cases of neurological disorders; however, these metals also have important regulatory functions and mediate cell signaling and plasticity. With the use of synchrotron X-ray fluorescence, our lab localized total, [...] Read more.
Biometals in the brain, such as zinc, copper, and iron, are often discussed in cases of neurological disorders; however, these metals also have important regulatory functions and mediate cell signaling and plasticity. With the use of synchrotron X-ray fluorescence, our lab localized total, both bound and free, levels of zinc, copper, and iron in a cross section of one hemisphere of a rat brain, which also showed differing metal distributions in different regions within the hippocampus, the site in the brain known to be crucial for certain types of memory. This review discusses the several roles of these metals in brain regions with an emphasis on hippocampal cell signaling, based on spatial mapping obtained from X-ray fluorescence microscopy. We also discuss the localization of these metals and emphasize different cell types and receptors in regions with metal accumulation, as well as the potential relationship between this physiology and behavior. Full article
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