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Cancers
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Lung Cancer: From Mechanisms of Action and Risk Factors in...
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Lung Cancer: From Mechanisms of Action and Risk Factors in Disease Onset to Management

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 891

Special Issue Editors

Dr. Roberto Fabiani

E-Mail Website
Guest Editor
Department of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
Interests: cancer chemoprevention; nutrition; olive oil; polyphenols; natural bioactive compounds; antioxidants; oxidative stress; genotoxicity; mutagenicity; apoptosis; cell cycle regulation
Special Issues, Collections and Topics in MDPI journals
Dr. Irene Giacchetta

E-Mail Website
Guest Editor
School of Specialization in Hygiene and Preventive Medicine, University of Perugia, Perugia, Italy
Interests: cancer; risk factor

Special Issue Information

Dear Colleagues,

Despite significant advances in prevention and treatment in recent decades, lung cancer is still the most important cause of cancer death worldwide. There is the need to understand the role played by risk factors, mechanisms of occurrence of this disease, and management. The purpose of this Special Issue is to highlight the latest advances in the field of lung cancer, from mechanisms of action to diagnosis and treatment options. The management of lung cancer has changed over the past decade. This Special Issue aims to establish the state of the art on this heterogeneous disease to increase our knowledge and help physicians fight this deadly disease. The scope of this Special Issue includes, but is not limited to, the following topics: cancer prevention, secondary prevention and disease management, and public health implications. Original research articles and literature reviews are welcome.

Dr. Roberto Fabiani
Dr. Irene Giacchetta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • non-small-cell lung cancer (NSCLC)
  • small-cell lung cancer (SCLC)
  • prevention
  • risk management
  • mechanisms

Published Papers (1 paper)

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Research

12 pages, 4335 KiB  
Article
Bronchopleural Fistula after Lobectomy for Lung Cancer: How to Manage This Life-Threatening Complication Using Both Old and Innovative Solutions
by Antonio Mazzella, Monica Casiraghi, Clarissa Uslenghi, Riccardo Orlandi, Giorgio Lo Iacono, Luca Bertolaccini, Gianluca Maria Varano, Franco Orsi and Lorenzo Spaggiari
Cancers 2024, 16(6), 1146; https://doi.org/10.3390/cancers16061146 - 14 Mar 2024
Viewed by 647
Abstract
Backgrounds: Our goal is to evaluate the correct management of broncho-pleural fistula (BPF) after lobectomy for lung cancer. Methods: We retrospectively reviewed our 25-years’ experience and reported our strategies and our diagnostic algorithm for the management of post-lobectomy broncho-pleural fistula. Results: Five thousand [...] Read more.
Backgrounds: Our goal is to evaluate the correct management of broncho-pleural fistula (BPF) after lobectomy for lung cancer. Methods: We retrospectively reviewed our 25-years’ experience and reported our strategies and our diagnostic algorithm for the management of post-lobectomy broncho-pleural fistula. Results: Five thousand one hundred and fifty (5150) patients underwent lobectomy for lung cancer in the period between 1998 and 2023. A total of 44 (0.85%) out of 5150 developed post-operative BPF. In 11 cases, BPF was solved by non-invasive treatment. In nine cases, direct surgical repair of the bronchial stump allowed BPF resolution. In 14 cases, a completion intervention was performed. In six cases, we performed open window thoracostomy (OWT) after lobectomy; in two cases, the BPF was closed by percutaneous injection of an n-butyl cyanoacrylate glue mixture. In two cases, no surgical procedure was performed because of the clinical status of the patient at the time of fistula developing. Thirty-day and ninety-day mortality from fistula onset was, respectively, 18.2% (eight patients) and 22.7% (ten patients). Thirty-day and ninety-day mortality after completion pneumonectomy (12 patients) was, respectively, 8.3% (one patient) and 16.6% (two patients). Conclusions: The correct management of BPF depends on various factors: timing of onset, size of the fistula, anatomic localization, and the general condition of the patient. In the case of failure of various initial therapeutic approaches, completion intervention or OWT could be considered. Full article
(This article belongs to the Special Issue Lung Cancer: From Mechanisms of Action and Risk Factors in Disease Onset to Management)
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