From Pathology to Therapeutics: The Long Journey in Cardio-Renal Diseases

Dear Colleagues,

It is well established that the heart and kidney are strongly interconnected, as much as primary disease of one of these organs often causes damage to the other. The hallmarks of cardio-renal disorders are the development of cardiorenal hypertrophy, heart failure, fibrosis, as well as alteration of body fluid, electrolytes, and acid-base kidney homeostasis. This cascade of complex and dynamic mechanisms spreading the damage to both organs is frequently tied to adverse clinical outcomes.

Improving the understanding of the pathophysiology of cardio-renal diseases can help find new biomarkers to be adopted for their direct management. Moreover, the establishment of innovative targeted therapies can attenuate the effects of the damage in one organ thus promoting multiorgan regeneration. In this context, the use of complex in vitro systems and new therapeutic approaches (biologics and cell-based therapy) can improve the research advances in important cardiorenal disorders such as heart failure, atherosclerosis, and diabetic nephropathy.

This Special Issue of Cells therefore invites contributions of review articles and original research papers studying the cardio-renal interaction using multiple complex systems and possible innovative therapeutic strategies for their treatment. For review articles, we encourage authors to include the multiple aspects of the cardio-renal pathologies considering physiological, biochemical, and molecular aspects of these multifaceted diseases.

Dr. Federica Collino
Dr. Stefania Bruno
Dr. Anna Maria Tolomeo
Guest Editors

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• cardio-renal disorders
• cardiovascular damage
• chronic kidney disease
• biomarkers
• -omics technologies
• therapeutic strategies
• cell-based therapy
• complex in vitro models.