Membrane Damage and Repair in Organelles

Dear Colleagues,

Organelle membranes play critical roles to compartmentalize organelle contents from cytosol and to maintain organelle functions in cells. Organelle membranes can be damaged by bacterial escape during infection, inorganic materials internalized from outside, and environmental change (such as osmolarity change). When organelle membranes are damaged, many molecular events are expected to occur. For example, organelle membrane tension is decreased, ions (such as Ca²⁺) leak into cytosol, proteins (such as Galectins) enter lumen from cytosol, sphingomyelin (in the luminal side of the membrane) is exposed to cytosol, the ESCRT complex is recruited to repair damaged membranes, and autophagy occurs to degrade damaged organelles. The process of membrane damage and repair has initially been studied in the plasma membrane; however, recent studies have started to reveal the molecular events for organelles.

This Special Issue focuses on membrane damage and repair in organelles and provides an overview of membrane damage caused by pathogen escape, inorganic materials, other methods used to damage organelles, the physical properties of organelle membranes, lipid characteristics, signaling after membrane damage, membrane repair, and the degradation of damaged organelles. This Special Issue highlights the recent advances and future research directions that are necessary to understand the membrane damage and repair in organelles.

Dr. Yoko Shiba
Guest Editor

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• membrane damage
• organelle
• pathogen
• inorganic material
• galectin