Molecular Insights: Bridging the Gap between Aging, Neurodegenerative Disease, and Cancer from Bench to Bedside

Dear Colleagues,

Aging, neurodegeneration, and cancer represent three of the most pressing health challenges facing our aging population. Aging is a natural process marked by accumulating cellular damage and physiological decline. Neurodegeneration involves the progressive dysfunction and death of neurons, resulting in disorders such as Alzheimer's disease and Parkinson's disease. Cancer is characterized by uncontrolled cellular proliferation and invasion.

While seemingly distinct in their pathogenesis, these conditions in fact share a number of key cellular and molecular mechanisms. Grasping the specific as well as the common underpinnings—from genomic instability to cellular senescence, epigenetics, and mitochondrial dysfunction—might unlock novel therapeutic targets and stratified interventions to delay or prevent the onset and progression of these debilitating and often fatal conditions.

This Special Issue, entitled "Molecular Insights: Bridging the Gap between Aging, Neurodegenerative Disease, and Cancer from Bench to Bedside", aims to showcase the latest advancements and breakthroughs in the complex connections between aging, neurodegeneration, and cancer, seeking to decipher the fundamental mechanisms driving the onset and progression of these conditions. These cellular and molecular insights are essential in the quest for early diagnosis, effective treatments, and, ultimately, a cure.

We are pleased to invite you to contribute original articles, reviews, communications, and other submissions. We look forward to your contributions to this Special Issue.

Dr. Maurizio Romano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• aging
• neurodegeneration
• cancer
• cellular senescence
• SASP
• stem cell exhaustion
• epigenetics
• metabolism
• mitochondria
• proteostasis
• inflammation
• immune aging
• DNA damage
• genomic instability
• cell cycle
• proliferation
• risk genes
• biomarkers
• therapeutics
• disease models