Molecular Mechanism behind Parkinson's Disease: From Triggers to Treatment
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 2912
Special Issue Editor
Interests: neurology; psychiatry; pain; Parkinson's disease; multiple sclerosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Basic research on chronic neurodegenerative disease entities often focuses on animal models and on findings from neuropathological, post-mortem studies. Both approaches are necessary to identify molecular mechanisms, which may finally represent the basis for the development of novel disease-modifying (respectively neuroprotective) therapies in chronic neurodegenerative processes such as Parkinson’s disease. The human brain may compensate the consequences of the initiation and the sometimes relapse-like progression of neurodegeneration only to a certain extent. The velocity of progression differs in an individual manner. The heterogeneity of disease symptoms and progression, in combination with the multiple and various complementary neuronal cell death mechanisms are the basis for new therapeutic approaches to disease modification in Parkinson’s disease beyond symptomatic dopamine substitution. This Special Issue aims to establish biological markers for risk factors of Parkinson’s disease to establish an earlier diagnosis of the neurodegenerative process and objective hallmarks of disease progression. This compilation on new biomarkers and therapies in Parkinson’s disease and related chronic neurodegenerative disorders aims to present the current available knowledge on the identification and development of biomarkers, associated molecular mechanisms and probable novel therapies in chronic neurodegeneration for future translation in clinical research.
Prof. Dr. Thomas Müller
Guest Editor
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Keywords
- Parkinson’s disease
- mechanisms of chronic neurodegeneration
- biomarkers
- cure
- neuroprotection
- disease modification
- risk factors
