Sickle Cell Disease: Pathogenesis, Diagnosis and Treatment

Dear Colleagues,

We are in an exciting era for sickle cell disease, with new drugs and gene therapies in the pipeline. With these opportunities come new questions: how do we select the best drug therapy and compare the efficacy of different gene therapy strategies? Along with these questions, there remains the question of if gene therapy is curative and even how to define a cure.

There are new devices, molecular tests, and sequencing strategies to help us answer these questions. In this Special Issue, we aim to describe the state of the science and review current applications for these new technologies. Articles describing ways to vet the safety and efficacy of gene therapy for SCD are welcome, as are articles describing omics studies or omics-based strategies that identify novel therapeutic pathways or elucidate sickle cell disease pathophysiology. Our major focus is on experimental cytology. We are also pleased to invite you to submit articles addressing new ways to assess red cell health and strategies that use existing or emerging biomarkers to identify acute complications or best second-line agents.

Dr. Vivien Sheehan
Dr. Ben Kopp
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• sickle cell disease
• vaso-occlusive events
• acute chest syndrome
• omics
• gene therapy
• red cell rheology
• microfluidics