Autophagy Meets Aging 2024
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Autophagy".
Deadline for manuscript submissions: 15 November 2024 | Viewed by 380
Special Issue Editors
Interests: metabolism; autophagy; mitochondria; genome instability; inflammation and aging
Special Issues, Collections and Topics in MDPI journals
2. Department of Geriatrics, Neuroscience and Orthopedics, Fondazione Policlinico Universitario "A. Gemelli", IRCCS, 00168 Rome, Italy
Interests: autophagy; biogerontology; biomarkers; exosomes; inflamm-aging; metabolic markers; mitochondria; mitochondrial DNA; mitophagy; mitochondrial damage
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Aging is marked by multiple biological disarrangements that predispose older individuals to increased vulnerability to the development of chronic diseases (e.g., cancer, diabetes, cardiovascular disease, neurodegeneration) and functional decline.
Declines in autophagy and cellular quality control systems are advocated as being among pillars of the aging process by contributing to the accrual of intracellular “waste” (e.g., protein aggregates, damaged mitochondria, and lipofuscin). Organelle-specific forms of autophagy (including mitophagy, which selectively targets mitochondria) have been identified. Due to the pro-inflammatory nature of some intracellular components, the coordinated activity of these recycling machineries is especially relevant for limiting inflamm-aging through efficient housekeeping.
This Special Issue aims to gather contributions on age-related changes in autophagy and other cellular quality control processes from different, yet complementary, points of view, by convening clinicians and basic researchers working in the field of biogerontology in humans and pre-clinical models. If the molecular determinants of these changes were to be unveiled, innovative anti-aging remedies and personalized interventions targeting cellular quality control could be developed for extending both health- and lifespan.
We therefore invite you to submit your latest original research or review articles to this Special Issue.
Prof. Dr. Christiaan Leeuwenburgh
Dr. Anna Picca
Guest Editors
Manuscript Submission Information
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Keywords
- aging
- autophagy
- cellular quality control
- mitochondrial dysfunction
- redox biology
- extracellular vesicles trafficking
- inflammation
- biomarkers
- omics
- behavioral and pharmacological interventions
