Cellular Signaling and Therapeutic Approaches of Pulmonary Fibrosis

Dear Colleagues,

Fibrosis is a progressive scarring disease that can affect virtually all the organs in the body and is estimated to account for almost half of all deaths in the United States alone. Pulmonary fibrosis exemplifies this disorder due to its poor prognosis and lack of curative treatment. The key pathogenic steps in pulmonary fibrosis involve epithelial cell disruption, myofibroblast differentiation, macrophage activation, and extracellular matrix deposition, and the interactions between these cell types and the molecular pathways behind these mechanisms represent interesting topics of research. Likewise, our knowledge regarding the reversal or resolution of fibrotic pathogenesis is limited and warrants further exploration.

This Special Issue will explore how cellular signaling contributes to pulmonary fibrogenesis and resolution, with the aim of highlighting potential novel therapeutic targets.

Dr. Jennifer Speth
Guest Editor

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• pulmonary fibrosis
• resolution
• cellular interactions