Vascular Dysfunction in Alzheimer’s Disease

Dear Colleagues,

Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that manifests as deteriorating cognitive function and memory decline. While the etiology of AD is multifactorial, involving genetic predisposition, environmental factors and lifestyle choices, a significant body of research has implicated vascular dysfunction as a critical component in the pathogenesis and progression of Alzheimer’s disease.

The exploration of vascular dysfunction in AD is essential for several compelling reasons. First, it provides a novel lens through which to view the disease's multifaceted mechanisms, challenging and expanding our understanding. Second, it illuminates the potential avenues for therapeutic intervention, with the tantalizing possibility that drugs targeting vascular health could improve or stabilize cognitive function in AD patients. Lastly, addressing vascular health may play a preventive role against AD, especially considering the overlapping risk factors that contribute to both vascular and cognitive decline.

This Special Issue will focus on the concept of vascular dysfunction in the context of AD, providing an overview of its role, the mechanisms involved and the implications for understanding and treating this complex condition.

Dr. Bhakta Prasad Gaire
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• vasculopathy in AD
• tight junction loss
• retinal vascular abnormalities
• vascular permeability
• vascular amyloidosis
• vascular inflammation