Hypoxia and Cancer: New Aspects 2.0

Dear Colleagues,

Interest in the effect of hypoxia, both on cancer and non-neoplastic cells, has continued to grow in recent years, as evidenced by the large number of publications on the topic according to PubMed. Another, small, testimonial of this interest is our first Special Issue on Cancer and Hypoxia. In this first collection, papers looking at basic physiological mechanisms, effects on pathways in cancer cells, and the role played in resistance to treatment and effects on the immune system were published, showing how broad this field is. The latter is one of the areas of investigation that has been recently expanding as the interaction between levels of cellular oxygenation and the immune system is becoming increasingly important in cancer. The oxygen level of cancer cells is also being recognized as affecting the behavior of the tumor-associated stroma. The study of hypoxia in both cancer cells and associated stroma is another emerging area where epigenetics is becoming an important component. Alongside this, the study of hypoxia in physiology, such as adaptation to high altitudes, is providing a wealth of data useful for cancer research.

All this considered, we have decided it would be a good idea to launch a second edition of the Special Issue on Cancer and Hypoxia and invite the scientific community to send us more data on hypoxia and cancer, from basic science to translational application. However, we also invite work on the physiology of hypoxia in non-neoplastic conditions, as dialogue between the cancer and non-cancer communities would certainly benefit both.

Thanks to all of you!

Prof. Dr. Francesco Pezzella
Prof. Dr. Mahvash Tavassoli
Guest Editors

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• hypoxia
• cancer
• physiology