The Dynamic Zebrafish Nervous System

Dear Colleagues,

The nervous system, composed of neurons and glia, is known for its dynamicity. Dysregulation of such dynamicity underlies neurodevelopmental, psychiatric, and neurodegenerative disorders. In the past, our understanding of dynamicity mostly relied on approaches that use in vitro-cultured neural cell types and tissue slices. In recent years, with the advancement of in vivo imaging technologies for microscopes and genetically encoded neural activity indicators, we are now able to visualize and understand the dynamics of intact nervous systems. Zebrafish, in particular larval zebrafish, with their optical clarity and relatively small brains that can be imaged in their entirety at cellular resolution, are making progress in ushering in a new understanding of nervous system dynamicity. As a highly tractable genetic system, zebrafish make available many mutations for genes associated with human neurological diseases.

This Special Issue will examine the use of zebrafish (both normal and mutants) in imaging and understanding nervous system dynamicity. Cell types of interest include both neurons and glia (e.g., astrocytes, microglia). Modalities of imaging include calcium imaging and voltage imaging. Computational tools for data analysis are also an important part of this Special Issue. 

Prof. Dr. Su Guo
Guest Editor

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• zebrafish
• calcium imaging
• mutant
• neurons
• microglia
• astrocytes
• in vivo
• computational