Hedgehog Signaling in Myelin Diseases and Inflammatory Disorders of the Nervous System—Second Edition

Dear Colleagues,

Until the end of the 20th century, proteins belonging to the Hedgehog family were essentially considered as morphogens acting at a distance from the cells that synthesized them via the establishment of a concentration gradient and controlling cell identities in the developing spinal cord. However, in recent decades, Hedgehog signaling has been found to be endowed with a multitude of other roles.

The involvement of Hedgehog signaling in the generation of oligodendrocytes, its requirement for proper development of peripheral nerve sheaths, as well as its implication in the maintenance of the blood–brain and blood–nerve barriers have raised the possibility that targeting Hedgehog signaling may open therapeutic perspectives towards demyelinating and inflammatory nervous system disorders.

The present Special Issue should provide an overview of the state of the art, namely, regarding the mechanisms underlying the involvement of Hedgehog signaling in myelin production, the therapeutic potential of Hedgehog signaling modulators in the process of myelin maintenance or regeneration, the contribution of Hedgehog signals to design cell therapies for myelin diseases, Hedgehog-mediated control of the blood–brain and blood–nerve barriers, and the role of Hedgehog signaling in glial cells participating in neuroinflammation.

Dr. Elisabeth Traiffort
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Hedgehog signaling
• myelination
• myelin repair
• neuroinflammation
• glial cells
• blood–brain barrier
• blood–nerve barrier
• hedgehog modulators
• cell therapy
• nerve injury

• Hedgehog Signaling in Myelin Diseases and Inflammatory Disorders of the Nervous System in Cells (4 articles)