Cell-to-Cell Metabolic Cross-Talk in Physiology and Pathology—2nd Edition

A project collection of Cells (ISSN 2073-4409).

Papers displayed on this page all arise from the same project. Editorial decisions were made independently of project staff and handled by the Editor-in-Chief or qualified Editorial Board members.

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Editors


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Guest Editor
Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale “A. Avogadro”, Via Solaroli 17, 28100 Novara, Italy
Interests: autophagy and protein metabolism in cancer and in neurodegeneration; epigenetics in cancer; nutraceuticals and probiotics in cancer and infectious diseases
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Guest Editor
Stephenson Cancer Center, Oklahoma University Health Science Center, Oklahoma, OK 73104, USA
Interests: cancer; cell signaling; non-coding RNA; tumor microenvironment
Special Issues, Collections and Topics in MDPI journals

Project Overview

Dear Colleagues,

We are delighted to present the second edition of the Special Issue on Cells, which continues to explore the intricate mechanisms and pathophysiological significance of the metabolic crosstalk between cells. This edition will feature a curated selection of papers from esteemed contributors, building upon the success of the inaugural edition.

The focus of this Special Issue remains on advancing our understanding of the dynamic interplay between cellular components, shedding light on the profound implications of the metabolic crosstalk in both physiology and pathology. The diverse range of topics covered in this collection reflects the multifaceted nature of cell-to-cell interactions, exploring key areas such as cell cycle regulation, the role of exosomes and extracellular vesicles, the interplay between cell adhesion and metabolism, the connection between cell death regulation and metabolism, the dynamic relationship between immune cells and the tissue microenvironment, and the compartmentalization of cellular signaling.

As we delve deeper into the complexities of exosomes, cell death, metabolism, diseases, autophagy, cell adhesion, cell migration, cell signaling, cell proliferation, and the intricate dynamics within the tissue microenvironment, this Special Issue aims to contribute valuable insights to the scientific community.

Submitted papers have undergone a rigorous peer review process, ensuring the publication of high-quality research results, developments and applications.

We hope that the knowledge shared within these pages will stimulate further research and discussions, fostering advancements in the field of cell biology and metabolic crosstalk.

Prof. Dr. Ciro Isidoro
Prof. Dr. Danny N. Dhanasekaran
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • exosomes
  • cell death
  • cell metabolism
  • autophagy
  • cell adhesion
  • cell migration
  • cell signaling
  • cell proliferation
  • tissue microenvironment
  • epigenetics

Related Special Issue

Published Papers (1 paper)

2024

23 pages, 9095 KiB  
Article
Characterizing the Tumor Microenvironment and Its Prognostic Impact in Breast Cancer
by Wenjuan Zhang, Alex Lee, Amit K. Tiwari and Mary Qu Yang
Cells 2024, 13(18), 1518; https://doi.org/10.3390/cells13181518 - 10 Sep 2024
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Abstract
The tumor microenvironment (TME) is crucial in cancer development and therapeutic response. Immunotherapy is increasingly recognized as a critical component of cancer treatment. While immunotherapies have shown efficacy in various cancers, including breast cancer, patient responses vary widely. Some patients receive significant benefits, [...] Read more.
The tumor microenvironment (TME) is crucial in cancer development and therapeutic response. Immunotherapy is increasingly recognized as a critical component of cancer treatment. While immunotherapies have shown efficacy in various cancers, including breast cancer, patient responses vary widely. Some patients receive significant benefits, while others experience minimal or no improvement. This disparity underscores the complexity and diversity of the immune system. In this study, we investigated the immune landscape and cell–cell communication within the TME of breast cancer through integrated analysis of bulk and single-cell RNA sequencing data. We established profiles of tumor immune infiltration that span across a broad spectrum of adaptive and innate immune cells. Our clustering analysis of immune infiltration identified three distinct patient groups: high T cell abundance, moderate infiltration, and low infiltration. Patients with low immune infiltration exhibited the poorest survival rates, while those in the moderate infiltration group showed better outcomes than those with high T cell abundance. Moreover, the high cell abundance group was associated with a greater tumor burden and higher rates of TP53 mutations, whereas the moderate infiltration group was characterized by a lower tumor burden and elevated PIK3CA mutations. Analysis of an independent single-cell RNA-seq breast cancer dataset confirmed the presence of similar infiltration patterns. Further investigation into ligand–receptor interactions within the TME unveiled significant variations in cell–cell communication patterns among these groups. Notably, we found that the signaling pathways SPP1 and EGF were exclusively active in the low immune infiltration group, suggesting their involvement in immune suppression. This work comprehensively characterizes the composition and dynamic interplay in the breast cancer TME. Our findings reveal associations between the extent of immune infiltration and clinical outcomes, providing valuable prognostic information for patient stratification. The unique mutations and signaling pathways associated with different patient groups offer insights into the mechanisms underlying diverse tumor immune infiltration and the formation of an immunosuppressive tumor microenvironment. Full article
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