The Role of Lysosomes in Modulating Cell Function
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Autophagy".
Deadline for manuscript submissions: closed (15 November 2021) | Viewed by 444
Special Issue Editors
Interests: podocytes; glomerular disease; intracellular trafficking; advanced imaging methods
Special Issue Information
Dear Colleagues,
Lysosomes are membrane bound organelles that have traditionally been thought of as the disposal units within the cell, breaking down cellular proteins, lipids and organelles. Recent work, however, has shown that lysosomes play an important role in regulating cellular function by coordinating the response to changes in the cellular milieu. Lysosomes have also been shown to communicate with other organelles and the plasma membrane, making them hubs for communication within and between cells. Lysosomal control of cell metabolic and catabolic pathways makes these organelles pivotal players in a wide variety of processes including nutrient sensing, intracellular trafficking, autophagy, drug sequestration, malignant transformation and stem cell fate determination. The primary focus of this topic will be the role of lysosomes in regulating cellular structure and function and the mechanisms underlying these pathways. An additional focus will be modulating lysosomal function and signalling to alter disease processes such as drug resistance, viral infection and metastasis.
Dr. Judith Blaine
Dr. James Dylewski
Guest Editors
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Keywords
- cellular metabolism
- autophagy
- trafficking
- cellular communication
- cell growth and survival
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