Rho GTPases in Health and Disease
A topical collection in Cells (ISSN 2073-4409). This collection belongs to the section "Cell Signaling".
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Interests: Rho GTPases; keratinocytes; mouse disease models
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Topical Collection Information
Dear Colleagues,
Rho GTPases are crucial organizers of the actin cytoskeleton with essential functions in cell migration and cell–cell contacts. In addition, Rho GTPases are involved in the regulation of stemness, proliferation and differentiation, and other cellular processes. Not surprisingly, this exciting family of molecules plays important roles in development and in disease. Genetically modified mice provided, in the last few years, important and often surprising insights into the in vivo function of Rho GTPases, and cellular studies in vitro suggested novel molecular mechanisms underlying the observed effects.
Still, many questions remain to be investigated in order to understand Rho GTPase function in development and disease. For example, what is the role of Rho GTPase crosstalk in vivo? What is the importance of posttranslational modifications of Rho GTPases? How crucial is the parallel activation of different effector pathways by an activated Rho GTPase? How is Rho GTPase function in 3D systems related to 2D models, the currently preferred system for the molecular analysis of Rho GTPase signalling?
For this Topical Collection of Cells on “Rho GTPases in Health and Disease” we invite scientists now to contribute review articles and primary research papers on the subject. Ideally, the review articles should, not only describe the current state-of-the-art, but also give personal opinions about future challenges and research goals in that area.
We hope that such a Topical Collection will make the scientific community aware of possible links of their work to Rho GTPases, which will trigger fruitful discussions, and that it will motivate young researchers to enter the Rho GTPase field and tackle the open questions of Rho GTPase functions in health and disease.
Dr. Cord Brakebusch
Collection Editor
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Keywords
- Rho GTPases
- Actin cytoskeleton
- In vivo disease models
- Rho GTPase regulation
- 3D in vitro models
- Development