Autophagosome Formation

Dear Colleagues,

Macroautophagy, often referred to as autophagy, is a cellular degradation process of immense importance in biology and medicine. This process entails the sequestration of portions of cytoplasm using a phagophore membrane that eventually closes to form a double-membrane autophagosome. When the autophagosome fuses with a lysosome, its content becomes degraded by lysosomal hydrolases. Dysregulated autophagy plays key roles in cancers, autoimmune diseases, infections, myopathies, and several other diseases, and is therefore imperative in characterizing the cellular and molecular basis of autophagy. One of the most long-standing questions in the autophagy field has concerned the origin of the autophagosome. This Special Issue of Cells focuses on recent progress in our understanding of autophagosome biogenesis, including the source of the phagophore membrane, the origin and function of seed vesicles, and the role of lipid transport for autophagosome biogenesis.

Dr. Yan Zhen
Dr. Ikuko Koyama-Honda
Guest Editors

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• ATG2
• ATG9
• autophagosome
• endosome
• membrane contact site
• omegasome
• phagophore
• lipid channel
• lipid scramblase