Mechanism-Based Therapeutic Interventions for Brain Diseases

Dear Colleagues,

This Special Issue, titled “Mechanism-Based Therapeutic Interventions for Brain Diseases”, covers a wide range of brain diseases including stroke, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis (MS), etc., using a number of mechanism-based therapeutic interventions targeting the neuronal/glial sites responsible for neuronal protection and neurogenesis, as illustrated below.

1. Brain cells death/injury can be triggered by external factors such as brain trauma, stroke, infection, aging, or intrinsic metabolic stress such as oxidative stress, inflammation, vascular dysfunction, the depletion of oxygen, glucose, and trophic factors.
2. Brain cells death/injury will lead to a massive release of glutamate, resulting in further neuronal death/injury known as “excitotoxicity” through a number of pathways, including mitochondrial, endoplasmic reticulum (ER), autophagy, and microglial stress pathways.
3. Therapeutic interventions for brain diseases could then be developed by targeting these stress pathways, including glutamate receptors, calcium channels, apoptosis, inflammation, oxidative stress, etc. In addition, the neurogenesis process through the mTOR or the neurotrophic factors pathways can also be targeted.

For this Special Issue, we welcome the submission of original research articles and reviews that highlight the molecular neuroprotection and neurogenesis mechanisms of brain diseases.

Prof. Dr. Jang-Yen Wu
Prof. Dr. Howard Prentice
Guest Editors

Manuscript Submission Information

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• stroke
• Alzheimer’s disease
• gene therapy
• neurotransmitters
• NMDA receptor
• excitotoxicity
• neuroprotection
• neurogenesis