Advances in DNA Repair Disorders Research: Molecular Mechanisms, Novel Therapies and Implications for Understanding Aging, Neurological Dysfunction and Cancer Progression

Dear Colleagues,

DNA repair defective diseases, encompassing a spectrum of disorders such as xeroderma pigmentosum, Trichotioystrophy, Cockayne syndrome, Ataxia-telangiectasia, Boom syndrome, Werener syndrome, Fanconi Anemia, and Hutchinson–Gilford progeria syndrome, underline the critical importance of DNA repair mechanisms in maintaining genomic stability. These conditions manifest as heightened susceptibility to cancer, accelerated aging, neurological dysfunction, and a plethora of other health challenges. A deep understanding of the molecular basis of these disorders is pivotal for the development of effective therapies. Moreover, studying the cells of these patients offers a unique opportunity to explore the complexities of DNA repair pathways and can serve as invaluable models to decipher the links between DNA repair, aging, and cancer.

This Special Issue of Cells aims to bring together the latest research and discoveries in the field in a collection of original research articles and reviews.

Topics include exploration of the intricate molecular mechanisms and signaling pathways at the basis of DNA repair-defective disorders, novel therapies and interventions designed to correct DNA repair deficiencies and the use of patients’ cells as a model to decipher the critical connection between DNA repair, aging, neurological dysfunction and tumorigenesis.

Dr. Manuela Lanzafame
Guest Editor

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• DNA repair diseases
• molecular mechanism
• signaling pathway
• therapies
• aging
• cancer
• neurological dysfunction