T-Cell Acute Lymphoblastic Leukaemia

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 217

Special Issue Editors


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Guest Editor
Department of Molecular Biotechnology and Health Sciences, Università degli Studi di Torino, Torino, Italy
Interests: acute leukemias; cell therapies; chemotherapy; stem cell transplantation
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Hematology & Transplant Centre, AOU Città della Salute e della Scienza, Torino, Italy
Interests: acute leukemia; molecular biology; myeloproliferative neoplasms

Special Issue Information

Dear Colleagues, 

T-cell acute lymphoblastic leukemias (T-ALL) are a rare form of hematological cancers that often have specific mutations and translocations, as well as having aggressive behavior, requiring urgent chemotherapy and, in many cases, an allogeneic stem cell transplant (SCT). T-ALL are 15–25% of all ALL diagnosed, but have a worse prognosis than B-ALL in both pediatric and adult settings. Understanding the several genetic changes of the leukemic cells has helped to find target therapies, such as small molecules and kinase inhibitors, to specifically act on the cancer cells and have less overall toxicity than conventional cytotoxic chemotherapy, which remains the current standard of care for up-front treatment. Moreover, the evaluation of minimal residual disease (MRD), either detecting specific T-cell receptor rearrangements by multiparametric flow cytometry or by the polymerase chain reaction, has a pivotal role in guiding therapeutic decision making. MRD-positive patients have a worse prognosis and benefit from more aggressive treatment, including HSCT. This Special Issue offers an open access forum that aims to bring together a collection of original research and review articles addressing the expanding field of T-cell acute leukemias. We hope to provide a stimulating resource of topics related to T-cell acute leukemias, such as molecular pathogenesis, epidemiology, treatments, and minimal residual disease. This summary and the keywords are intended as a guide for potential authors, as well as to clarify the background and aims of the Special Issue (for recent examples of Special Issue websites, please see https://www.mdpi.com/journal/cells/special_issues/cellular_stress).

Dr. Benedetto Bruno
Dr. Giuseppe Lanzarone
Guest Editors

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Keywords

  • T-cell leukemias
  • molecular pathogenesis
  • immune phenotype
  • T-cell leukemia epidemiology
  • T-cell ontogeny
  • transplantation in T-cell leukemia
  • target therapies

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Published Papers

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