The Biology of Aging and Cancer

Dear Colleagues,

Aging is a complex phenomenon caused by the time-dependent loss of cellular homeodynamics and consequently of physiological organismal functions leading to increased morbidity (e.g., the so-called age-related diseases, including cancer) and mortality. These processes are affected by genetic, environmental and life-style factors and are marked by the gradual accumulation of stressors and damaged biomolecules (including DNA and proteins) due to the time-dependent decline of stress resistance. Failure to eliminate genome and/or proteome instability by the respective damage-response pathways that constitute the pillars of a highly interconnected “defensive” network eventually compromises all aspects of cellular functionality, leading also to deregulated mitochondrial function which alters cell metabolism and energetics. These functional readouts are also hallmarks of tumorigenesis. In parallel, the age-related accumulation of senescent cells exerts detrimental effects fostering aging and cancer; thus, it is important to develop the rapidly expanding field of senotherapeutic agents which selectively eliminate senescent cells or inhibit their catabolic and/or inflammatory phenotype. Research or review articles addressing these topics or investigating the functional cross-talk of the different modules involved in aging and tumorigenesis in cells and/or models organisms, along with the age- and/or cancer-related deregulation of nutrients sensing and signaling pathways, will be considered for this Special Issue. Novel studies on natural products or small molecules targeting aging, senescent or tumor cells will also be part of this Special Issue.

Prof. Dr. Ioannis Trougakos
Prof. Dr. Vassilis Gorgoulis
Dr. Dimitris Kletsas
Guest Editors

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• ageing
• cancer
• senescence