Glucocorticoid-Induced Proteins Annexin A1 and GILZ in Inflammation

Dear Colleagues,

Glucocorticoids (GCs) are endogenous hormones that are critical for organism homeostasis and adaptation to environmental conditions. Because of their anti-inflammatory actions, synthetic GCs are extensively used in clinical practice to treat several inflammatory conditions, representing the first successful use of an endogenous molecule for therapeutic purposes. However, long-term use is limited by the development of serious adverse effects, and administration is discouraged in infectious settings, as the immunosuppressive actions of GCs may favor pathogen propagation. Glucocorticoid-induced leucine zipper (GILZ) and Annexin A1 (AnxA1) are GC-induced proteins intrinsically involved with the anti-inflammatory functions of GCs without the associated adverse metabolic effects. Furthermore, there is a genuine interest in GC-induced proteins' ability to shift the amplification phase of inflammation towards the resolution yet helping the host to deal with a given infection. Understanding how endogenous points of control within the inflammatory pathways operate and identifying the consequences of the disruption of these circuits might guide the development of novel treatment approaches for chronic inflammation, autoimmune diseases, and infections. This Collection of Cells welcomes original articles and reviews covering the broad spectrum of processes in which GC-induced proteins are involved, both in health and disease.

Prof. Dr. Lirlândia Pires De Sousa
Dr. Michelle Sugimoto
Dr. Luciana Tavares
Dr. Stefano Bruscoli
Collection Editors

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