Exploring the Brain-Gut Connection in Children

A special issue of Children (ISSN 2227-9067).

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 894

Special Issue Editors


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Guest Editor
Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN 37232, USA
Interests: esophageal diseases; functional bowel disorder; inflammatory bowel disease (IBD); interventional endoscopy; pediatric gastroenterology, hepatology and nutrition

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Guest Editor
Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
Interests: neurogastroenterology; motility and functional gastrointestinal disorders (FGIDs)

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Guest Editor
Pediatric Gastroenterology, Hepatology and Nutrition Division, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Interests: pediatric gastroenterology; functional bowel disorders; digestive disorders
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Special Issue Information

Dear Colleagues,

There is growing awareness of the bi-directional relationship between mental health and gastrointestinal symptoms in children. There is a complex interaction between the enteric nervous system, the microbiome, and the central nervous system which is influenced by extrinsic environmental factors. This can manifest as gastrointestinal symptoms in children with psychosocial stressors and, conversely, present as mental health disorders in children with gastrointestinal disease. It can explain why children with anxiety and depression experience disorders of visceral hypersensitivity, and why many children with gastrointestinal disease develop depression, anxiety, fatigue, and decreased quality of life. This interplay, however, can be advantageous when harnessed for treatment. We know that many cognitive strategies including cognitive behavioral therapy, hypnosis, mindfulness, and restorative sleep practices, and medications to address serotonin imbalance can also be successfully used to treat gastrointestinal symptoms. Neuromodulation and acupuncture, in addition, affect the autonomic nervous system to restore the brain–gut imbalance.

This Special Issue’s focus is on all aspects of the mind–gut connection and how we can integrate that connection into our understanding and treatment approaches for pediatric gastroenterology patients.

Dr. Alexandra C. Russell
Dr. Neha R. Santucci
Dr. Miguel Saps
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mind-body connection
  • microbiome
  • functional gastrointestinal disorders
  • mind-body integration

Published Papers (1 paper)

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Review

19 pages, 2041 KiB  
Review
The Potential Impact of the Gut Microbiota on Neonatal Brain Development and Adverse Health Outcomes
by Maria Tzitiridou-Chatzopoulou, Jannis Kountouras and Georgia Zournatzidou
Children 2024, 11(5), 552; https://doi.org/10.3390/children11050552 - 5 May 2024
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Abstract
Over the past decade, microbiome research has significantly expanded in both scope and volume, leading to the development of new models and treatments targeting the gut–brain axis to mitigate the effects of various disorders. Related research suggests that interventions during the critical period [...] Read more.
Over the past decade, microbiome research has significantly expanded in both scope and volume, leading to the development of new models and treatments targeting the gut–brain axis to mitigate the effects of various disorders. Related research suggests that interventions during the critical period from birth to three years old may yield the greatest benefits. Investigating the substantial link between the gut and brain during this crucial developmental phase raises fundamental issues about the role of microorganisms in human health and brain development. This underscores the importance of focusing on the prevention rather than the treatment of neurodevelopmental and neuropsychiatric disorders. The present review examines the gut microbiota from birth to age 3, with a particular focus on its potential relationship with neurodevelopment. This review emphasizes the immunological mechanisms underlying this relationship. Additionally, the study investigates the impact of the microbiome on cognitive development and neurobehavioral issues such as anxiety and autism. Importantly, it highlights the need to integrate mechanistic studies of animal models with epidemiological research across diverse cultures to better understand the role of a healthy microbiome in early life and the implications of dysbiosis. Furthermore, this review summarizes factors contributing to the transmission of gut microbiome-targeted therapies and their effects on neurodevelopment. Recent studies on environmental toxins known to impact neurodevelopment are also reviewed, exploring whether the microbiota may mitigate or modulate these effects. Full article
(This article belongs to the Special Issue Exploring the Brain-Gut Connection in Children)
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