Clinical Advances and Perspectives on Neonatal Surgery—Volume II

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Surgery".

Deadline for manuscript submissions: 1 March 2025 | Viewed by 1002

Special Issue Editor


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Guest Editor
Pediatric Surgery, Ca' Foncello Hospital, 31100 Treviso, Italy
Interests: neonatal surgery; prenatal diagnosis; multidisciplinary counselling; perinatal management; anorectal malformations; esophageal atresia; congenital diaphragmatic hernia; congenital pulmonary airway malformations; ECMO; transition of care; laparoscopy; thoracoscopy; gastro-esophageal reflux; dysphagia
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Special Issue Information

Dear Colleagues,

As Guest Editor of the Special Issue entitled “Clinical Advances and Perspectives on Neonatal Surgery”, it is with great pleasure that I invite you to submit your works to the journal Children.

As we all know, the advancement of diagnostic techniques and surgical methods has enabled many malformations and neonatal conditions to be properly managed. The technical surgical aspects have been implemented together with a more comprehensive knowledge of fetal and neonatal physiology, thus allowing for substantially improved outcomes for many neonatal surgical conditions.

Considering the success and popularity of the Special Issue “Clinical Advances and Perspectives on Neonatal Surgery” previously published in the journal Children (https://www.mdpi.com/journal/children/special_issues/Advances_Neonatal_Surgery), we are now releasing a Second Issue aims to collect and share the most recent clinical and research advancements in the treatment of those malformations that require prompt and skilled surgical expertise. In this Special Issue of Children, senior investigators are welcome to invite mentees and colleagues to co-author submissions under their supervision. We look forward to receiving your contributions.

Prof. Dr. Paola Midrio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • congenital malformations
  • esophageal atresia
  • anorectal malformations
  • laparoscopy
  • thoracoscopy
  • prenatal diagnosis
  • neonatal dysphagia
  • congenital diaphragmatic hernia
  • ECMO
  • neonatal enterostomy
  • congenital intestinal obstruction

Published Papers (1 paper)

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Research

10 pages, 957 KiB  
Article
Secondary Carnitine Deficiency in Neonates and Infants Requiring Surgery for Intestinal Obstructions—An Underestimated and Undermanaged Problem
by Sheng-Yang Huang, Chia-Man Chou and Hou-Chuan Chen
Children 2024, 11(2), 147; https://doi.org/10.3390/children11020147 - 24 Jan 2024
Viewed by 658
Abstract
This study aims to elucidate the relationship between intestinal obstruction and carnitine deficiency in neonates and infants. We retrospectively reviewed medical records of 330 neonates and infants, younger than six months, who underwent surgery for intestinal obstruction at our institute from January 2009 [...] Read more.
This study aims to elucidate the relationship between intestinal obstruction and carnitine deficiency in neonates and infants. We retrospectively reviewed medical records of 330 neonates and infants, younger than six months, who underwent surgery for intestinal obstruction at our institute from January 2009 to April 2022. The analysis focused on clinical symptoms, related signs, complications, and etiology of the intestinal obstruction. Tandem mass spectrometry (MS/MS) or urine organic acid analysis was conducted for 47 patients, revealing carnitine deficiency in 16 patients. The incidence of carnitine deficiency was 34.0% in the suspicious group and 4.8% overall, significantly higher than in the general population in Taiwan. Notably, patients with carnitine deficiency experienced prolonged ileus, with a mean fasting duration of 41.7 days (range 7.8–65.5 days), compared to 10.8 days (range 8.2–13.4 days) in patients without carnitine deficiency. Carnitine replacement therapy was administered to twelve patients at dosages ranging from 32 to 90 mg/kg/day. One patient exhibited a drug allergy with skin rashes. Our findings suggest that carnitine deficiency should be considered in cases of neonatal and infant intestinal obstruction. Replacement therapy is straightforward and can be prognostically beneficial for some patients. Therefore, we recommend generalizing MS/MS and urine organic acid analysis, particularly for patients with prolonged ileus. Full article
(This article belongs to the Special Issue Clinical Advances and Perspectives on Neonatal Surgery—Volume II)
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