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Coatings
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Advances in Functional Bio-Coatings
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Advances in Functional Bio-Coatings

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Bioactive Coatings and Biointerfaces".

Deadline for manuscript submissions: 22 February 2025 | Viewed by 3213

Special Issue Editors

Dr. Mosab Kaseem

E-Mail Website
Guest Editor
Department of Nanotechnology and Advanced Materials Engineering, Sejong University, Seoul 05006, Republic of Korea
Interests: corrosion matter of protective metallic materials via plasma electrolysis; surface modification via organic–inorganic conjugation; electrochemical interpretation per equivalent circuit model; plasticity control and mechanical modeling of nanostructured crystalline solid; biodegradable polymers; development of bioactive coatings on metallic materials
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Burak Dikici

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Ataturk University, Erzurum 25240, Turkey
Interests: manufacturing processes of bio-coatings; in vitro corrosion of biomaterials; biodegradable metallic materials; high-entropy alloy coatings; sol–gel; PVD/CVD-based coatings; bioceramic coatings; plasma electrolytic oxidation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bio-functional coatings have become the most efficient method for satisfying many therapeutic needs, in addition to producing excellent corrosion resistance and good mechanical qualities. For this Special Issue, we invite submissions exploring the latest advances in functional bio-coatings. In particular, the topics of interest include but are not limited to: manufacturing processes of bio-coatings, in vitro and in vivo responses of bio-coatings, the functionality of bio-coatings, biodegradable coatings, drug-delivery coatings, high-entropy alloy coatings, bioceramic coatings, cold spray deposition, thermal spray deposition, laser cladding technologies, sol–gel deposition, plasma electrolytic oxidation bio-coatings,  and PVD- and CVD-based bio-coatings. All manuscripts will be peer-reviewed, and those accepted will be immediately published online as a Special Issue entitled “Advances in Functional Bio-Coatings”. We welcome original research and review articles showcasing achievements and developments and providing guidance for developing functional bio-coatings.

Dr. Mosab Kaseem
Prof. Dr. Burak Dikici
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional bio-coatings
  • biomaterials
  • surface treatment
  • drug delivery
  • biocompatibility
  • corrosion
  • mechanical properties
  • antibacterial properties
  • cell viability

Published Papers (2 papers)

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Research

17 pages, 3539 KiB  
Article
Chitosan-Caffeic Acid Antibacterial Coating for PDMS Surfaces: A Sustained Moxifloxacin Release and Prolonged Coating Adhesion
by Felipe da Silva Veloso, Pascale Chevallier, Helton José Wiggers, Francesco Copes, Bernard Drouin and Diego Mantovani
Coatings 2024, 14(3), 291; https://doi.org/10.3390/coatings14030291 - 28 Feb 2024
Viewed by 1033
Abstract
Central venous catheters (CVCs) are largely used to administer chemotherapy, hemodialysis, and other treatments. Mostly made of polydimethylsiloxane (PDMS), these medical devices present an intrinsic risk of infection due to the possible formation of biofilm, thus increasing the risk of complications. Drug-releasing polymer [...] Read more.
Central venous catheters (CVCs) are largely used to administer chemotherapy, hemodialysis, and other treatments. Mostly made of polydimethylsiloxane (PDMS), these medical devices present an intrinsic risk of infection due to the possible formation of biofilm, thus increasing the risk of complications. Drug-releasing polymer coatings are a well-recognized strategy for combating biofilm formation. However, adhesion of the coating to the substrate over time is a major challenge. Therefore, this work aimed to design a chitosan-based coating designed to have maximum adhesion and stability to guarantee sustained drug release and antibacterial properties for at least 14 days. A coating composed of chitosan (CS) as a drug carrier, caffeic acid (CA) and copper sulphate (Cu) as crosslinkers, and moxifloxacin (Mox) as an antibiotic, was deposited through a controlled casting process onto functionalized PDMS surface. PDMS surface modification was investigated by X-ray photoelectron spectroscopy (XPS), and Fourier-transfer infrared (FTIR). Antibiotic release over time was measured in pseudo-physiological conditions (pH 7.4 and at 37 °C). Indirect cytotoxicity assays were performed on human dermal fibroblasts (HDF). The adhesion of the as-designed coating was evaluated by a specially designed pull-off test, before and after aging for 14 days in PBS. XPS and FTIR analyses confirmed the successful PDMS surface modification. The CS-CA-Cu-Mox coating resulted in being non-cytotoxic towards HDF and exhibited sustained moxifloxacin release for up to 49 days. Furthermore, the CS-CA and CS-CA-Cu coatings presented antibacterial activity for 21 days against E. coli, and for 14 days against S. aureus. Importantly, the coating maintained stable adhesion after 14 days in pseudo-physiological conditions. This study provides new insights into the adhesion behavior of polymeric coatings for medical devices, which is rarely reported in the literature. Full article
(This article belongs to the Special Issue Advances in Functional Bio-Coatings)
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17 pages, 6065 KiB  
Article
Surface Modification of Pure Mg for Enhanced Biocompatibility and Controlled Biodegradation: A Study on Graphene Oxide (GO)/Strontium Apatite (SrAp) Biocomposite Coatings
by Oktay Yigit, Turan Gurgenc, Burak Dikici, Mosab Kaseem, Carl Boehlert and Ersin Arslan
Coatings 2023, 13(5), 890; https://doi.org/10.3390/coatings13050890 - 9 May 2023
Cited by 2 | Viewed by 1496
Abstract
Magnesium alloys have excellent biodegradability but suffer from high corrosion rates and unfavorable biological responses. Thus, a surface modification strategy to regulate the corrosion rate and enhance biocompatibility is required. In this study, pure Mg substrate surfaces were coated with strontium apatite (SrAp) [...] Read more.
Magnesium alloys have excellent biodegradability but suffer from high corrosion rates and unfavorable biological responses. Thus, a surface modification strategy to regulate the corrosion rate and enhance biocompatibility is required. In this study, pure Mg substrate surfaces were coated with strontium apatite (SrAp) and graphene oxide (GO) biocomposite structures using the hydrothermal method to increase the biocompatibility of the surface of the Mg and obtain a moderate biodegradation rate. The effect of the GO concentration (0, 2, 4, and 6 wt.%) on the surface microstructure and its corrosion behavior were systematically studied. The corrosion behavior of the coatings was characterized in-vitro using the electrochemical polarization method in Hank’s solution. An EDS-connected SEM was used to examine the coatings’ surface properties. The functional groups of the coatings were identified using ATR-IR spectroscopy. To determine the degree of crystallization and examine the elemental distribution of the coatings, an XRD was used with a grazing incidence attachment. The XRD and SEM-EDS results showed that increasing the GO ratio in the SrAp-based coatings significantly enhanced the homogeneity and crystallinity, and the ATR-IR spectroscopy revealed that the SrAp/GO coatings were rich in functional groups, including hydroxyl, phosphate, and carbonate groups, that are known to promote bone formation and regeneration. The results of the electrochemical polarization tests demonstrated a considerable decrease in the corrosion rates for the samples with SrAp matrix and GO coatings. Additionally, the coatings containing GO exhibited higher polarization resistance (Rp) values, indicating their potential as a promising surface modification technique for biodegradable implants. These findings suggest that incorporating GO into the SrAp coatings could enhance their biocompatibility and provide a moderate biodegradation rate, which is desirable for biomedical applications. Full article
(This article belongs to the Special Issue Advances in Functional Bio-Coatings)
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