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Coatings
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Biomimetic Drug Delivery Coating
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Biomimetic Drug Delivery Coating

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Surface Coatings for Biomedicine and Bioengineering".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 4111

Special Issue Editor

Dr. Yuelian Liu

E-Mail Website
Guest Editor
Oral Implantology and Prosthetic Dentistry Academic Centre for Dentistry Amsterdam (ACTA), VU University of Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The Netherlands
Interests: biomimetic coating; osteointegration; bone regeneration; bone growth factors; drug delivery; tissue engineering; calcium phosphate; implant dentistry; implant surface modification; osteoinduction; osteoconduction; slow release system
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomimetic coatings have been developed for bone regeneration and repair because of their biocompatibility and osteoconductivity. They can be rendered osteoinductive by incorporating an osteoinductive agent such as bone morphogenetic protein 2 (BMP-2) into the crystalline lattice in physiological situations. The biomimetic calcium phosphate coating enables a controlled, slow, and local release of growth factors when it undergoes cell-mediated coating degradation induced by multinuclear cells such as osteoclasts and foreign body giant cells, which mimics a physiologically similar release mode.

The goal of this Special Issue is to present the major current areas of research and development in biomimetic coatings for biomaterials. The coating techniques, physico-chemical properties, and potential as drug carrier should be discussed, and the peri-clinical research results and the clinical related applications in implant dentistry as well as in orthopedics will be discussed. Biomimetic coatings may open a way forward for drug delivery and tissue engineering.

Dr. Yuelian Liu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomimetic coating
  • drug delivery
  • tissue engineering

Published Papers (1 paper)

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Review

19 pages, 3072 KiB  
Review
Biomimetic Calcium Phosphate Coating as a Drug Delivery Vehicle for Bone Tissue Engineering: A Mini-Review
by Xingnan Lin, Jiping Chen, Ying Liao, Janak Lal Pathak, Huang Li and Yuelian Liu
Coatings 2020, 10(11), 1118; https://doi.org/10.3390/coatings10111118 - 20 Nov 2020
Cited by 18 | Viewed by 3274
Abstract
The high incidence of bone defect cases necessitates a rapid development of cost-effective bone tissue engineering approaches. Bone growth factors such as bone morphogenetic protein-2 (BMP-2) play a vital role in bone tissue engineering. The osteoinductive efficacy of BMP-2 and other osteogenic growth [...] Read more.
The high incidence of bone defect cases necessitates a rapid development of cost-effective bone tissue engineering approaches. Bone growth factors such as bone morphogenetic protein-2 (BMP-2) play a vital role in bone tissue engineering. The osteoinductive efficacy of BMP-2 and other osteogenic growth factors is highly dependent on their dose and delivery mode. Slow and sustained delivery of a low dose of BMP-2 promotes bone defect healing. However, the burst release of a high dose of BMP-2 not only fails to promote bone healing but also causes adverse local and systemic effects. The biomimetic calcium phosphate (BioCaP) coating technique guarantees a slow, gradual, and local release of BMP-2 to mimic its natural release from the bone matrix under physiological conditions. Therefore, BioCaP coatings have long been regarded as a promising drug carrier for growth factors. In this mini-review, we give a brief introduction to BioCaP coatings regarding their preparation techniques, physicochemical properties, potential as a drug carrier, ability to suppress foreign body reactivity, and their preclinical application in ectopic and orthotopic models. Finally, the current challenges and future prospects of BioCaP coatings are discussed. Full article
(This article belongs to the Special Issue Biomimetic Drug Delivery Coating)
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