Dear Colleagues,

Emerging technologies in genomics, transcriptomics, metagenomics, and other life science areas are generating an increasing amount of complex data and information. These recent changes related to emerging technologies have made the role of computer science (both in theoretical and applied aspects) much more critical in all the bioinformatics research directions. In order to tackle the growing complexity associated with the management of huge amount of data, researchers need to explore, develop, and apply novel computational concepts, methods, tools, and systems. Many of these new approaches are likely to involve advanced and large-scale computing techniques, computational approaches, technologies and infrastructures.

This Special Issue invites submissions on topics related to these research directions in bioinformatics, such as high-performance architectures and systems, distributed computing (e.g., grid, cloud, peer-to-peer, Web services, e-infrastructures), computational simulation (mechanistic, stochastic, multi-model), algorithms (theoretical and experimental aspects) design and analysis, applied bioinformatics (analysis pipelines, software tools, preprocessing, analysis and integration of clinical and omics data), and artificial and computational intelligence (machine learning, agents, evolutionary techniques, and bio-inspired methods).

The Special Issue also specifically invites extended versions of papers presented at the “Workshop on Biomedical and Bioinformatics Challenges for Computer Science”. Submitted papers should be extended to the size of regular research or review articles with 50% extension of new results. All submitted papers will undergo our standard peer-review procedure. Accepted papers will be published in Open Access format in Computers and collected together in this Special Issue website.

Dr. Giuseppe Agapito
Prof. Mario Cannataro
Dr. Mauro Castelli
Dr. Riccardo Dondi
Prof. Rodrigo Weber dos Santos
Dr. Italo Zoppis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Computers is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• High-performance architectures and systems (e.g. multicore, GPU);
• Distributed computing (e.g. grid, cloud, peer-to-peer, Web services, e-infrastructures);
• Computational simulation (mechanistic, stochastic, multi-model);
• Algorithms (theoretical and experimental aspects);
• Applied bioinformatics (analysis pipelines, tools, applications);
• Artificial and computational intelligence (machine learning, agents, evolutionary techniques, bio-inspired methods).