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Research about Vital Organic Chelates and Metal Ion Complexes Volume...
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Research about Vital Organic Chelates and Metal Ion Complexes Volume II

A special issue of Crystals (ISSN 2073-4352). This special issue belongs to the section "Organic Crystalline Materials".

Deadline for manuscript submissions: closed (30 October 2023) | Viewed by 5970

Special Issue Editor

Dr. Moamen S. Refat

E-Mail Website
Guest Editor
Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
Interests: charge-transfer complexes; metal–acid complexes; schiff base complexes; metal–drug interactions; metal–dye complexes; crystal structures
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metal ion complexes is a rapidly developing field with enormous potential for applications that provides new possibilities for the pharmaceutical industry. It is expected that increasing knowledge about the role of minerals in biochemistry will provide an area for designing new drugs in many other areas as well, for example, neuropharmacology and anti-potency agents. Advances in coordination chemistry rely heavily on an understanding of not only the thermodynamics of reactions, but also the kinetics of mineral complexes under biologically relevant conditions. Metals are essential cellular components that function in many biochemical processes that are indispensable to living organisms. Transition metal complexes are important in catalysis, material synthesis, photochemistry, and biological systems. Inorganic medicinal chemistry can exploit the unique properties of metal ions to design new drugs. The use of metals and their complexes for medicinal purposes has been present throughout history. With advances in inorganic chemistry, the role of transition metal complexes as therapeutic compounds is becoming increasingly important. Recent advances in inorganic chemistry have made it possible to form a few transition metal complexes of organic interest that can be used as therapeutic agents. This review clarifies the role of metals and recent advances in medicinal organic biochemistry with new approaches to the design and application of innovative metal-based drugs.

Dr. Moamen S. Refat
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Crystals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metal complexes
  • metal-based drugs
  • medicinal inorganic chemistry
  • crystals
  • nanomaterials and applications
  • composites

Published Papers (4 papers)

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Research

Jump to: Review

17 pages, 4282 KiB  
Article
D,L-Citrullinato-bipyridine Copper Complex: Experimental and Theoretical Characterization
by Diego Ramírez-Contreras, Amalia García-García, Angel Mendoza, Laura E. Serrano-de la Rosa, Brenda L. Sánchez-Gaytán, Francisco J. Melendez, María Eugenia Castro and Enrique González-Vergara
Crystals 2023, 13(9), 1391; https://doi.org/10.3390/cryst13091391 - 19 Sep 2023
Viewed by 1055
Abstract
Citrulline is a non-protein amino acid that acts as a metabolic intermediate in the urea cycle and arginine synthesis. It is present in some foods, although its name derives from watermelon (Citrullus vulgaris), from which it was first identified. Under normal [...] Read more.
Citrulline is a non-protein amino acid that acts as a metabolic intermediate in the urea cycle and arginine synthesis. It is present in some foods, although its name derives from watermelon (Citrullus vulgaris), from which it was first identified. Under normal conditions, Citrulline exists as a zwitterion in aqueous solutions since its carboxylic and amine groups can act as Lewis donors to chelate metal cations. In addition, Citrulline possesses in the aliphatic chain a terminal ureide group, which could also coordinate. Although Citrulline is comparable to other classical amino acids, its coordination chemistry has yet to be explored. Only two metal complexes have been reported, and the copper complex is a polymeric and insoluble material. As part of our search for active Casiopeina® analogs, we created a more soluble complex by combining 2,2′-Bipyridine into a new mixed material, resulting in the mononuclear complex [Cu(Bipy)(Citr)(H2O)(NO3)]·H2O. Single-crystal X-ray diffraction, spectroscopic methods (FT-IR, UV-Vis, Raman), and mass spectrometry characterized the material. Interestingly, both isomers of Citrulline, R(D), and S(L) are present in the same crystal. In addition, the molecular structure and electronic properties of the complex were calculated using density functional theory (DFT). Non-covalent interactions were characterized using the atoms-in-molecules (AIM) approach and Hirshfeld surface (HS) analysis. This ternary complex containing Citrulline and 2,2′-Bipyridine will be used for docking calculations and preliminary biological studies using calf thymus DNA (CT-DNA) and plasmid pUC19 as a first approximation to cytotoxic activity against cancer cell lines. Full article
(This article belongs to the Special Issue Research about Vital Organic Chelates and Metal Ion Complexes Volume II)
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12 pages, 2527 KiB  
Article
Synthesis and Spectroscopic Characterizations of Some Essential Metal Ion (MgII, CaII, ZnII, and FeIII) Pipemidic Acid Chemotherapeutic Agent Complexes
by Asma S. Al-Wasidi
Crystals 2023, 13(4), 596; https://doi.org/10.3390/cryst13040596 - 1 Apr 2023
Cited by 1 | Viewed by 964
Abstract
The assignments structures of the four 1:1 pipemidic acid (pipH)–magnesium(II), calcium(II), zinc(II), and iron(III) complexes, [Mg(pip)(H2O)3(Cl)].6H2O, [Ca(pip)(H2O)3(Cl)].2H2O, [Zn(pip)(H2O)3(Cl)].4H2O, and [Fe(pip)(H2O)2(Cl)2 [...] Read more.
The assignments structures of the four 1:1 pipemidic acid (pipH)–magnesium(II), calcium(II), zinc(II), and iron(III) complexes, [Mg(pip)(H2O)3(Cl)].6H2O, [Ca(pip)(H2O)3(Cl)].2H2O, [Zn(pip)(H2O)3(Cl)].4H2O, and [Fe(pip)(H2O)2(Cl)2].6H2O, (where pip = deprotonated pipemidic), were synthesized through the chemical reactions of MgCl2.6H2O, CaCl2.2H2O, ZnCl2, and FeCl3.6H2O metal salt chlorides with pipH chemotherapeutic agent ligand in a methanolic solvent. The microanalytical analysis CHN, conductance, (infrared (FTIR) and electronic (UV–Vis.)) spectra, and thermogravimetric measurements (TG) have been utilized to discuss the solid isolated complexes. The X-ray powder diffraction (XRD) analysis and the transmission electron microscopy (TEM) confirm the nanostructured form of the synthesized pip complexes. The deprotonated pipH ligand is coordinated to Mg(II), Ca(II), Zn(II), and Fe(III) metal ions through the two oxygen atoms of the carbonyl (quinolone group) and carboxylic group. The thermodynamic parameters (energy, E*), (entropy, ΔS*), (enthalpy, ΔH*), and (Gibbs free energy, ΔG*) of activation have been estimated based on thermogravimetric curves using “Coats–Redfern and Horowitz–Metzeger non–isothermal” methods. Full article
(This article belongs to the Special Issue Research about Vital Organic Chelates and Metal Ion Complexes Volume II)
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18 pages, 6007 KiB  
Article
Synthesis of Bivalent Ni(II), Cu(II) and Zn(II) Complexes of Azodicarbonamide in Mixture of Methanol and Aqueous Solvents: Spectral Characterizations and Anti-Microbial Studies
by Ayman A. O. Younes, Abdel Majid A. Adam, Moamen S. Refat, Asma S. Al-Wasidi, Abdulrahman A. Almehizia, Mohamed A. Al-Omar, Ahmed M. Naglah, Abdulrahman M. Al-Obaid, Hamad M. Alkahtani, Ahmad J. Obaidullah, Mohamed Y. El-Sayed and Kareem A. Asla
Crystals 2023, 13(3), 367; https://doi.org/10.3390/cryst13030367 - 21 Feb 2023
Cited by 1 | Viewed by 1969
Abstract
Three new transition-metal complexes were produced by refluxing azodicarbonamide (ADCA) with nickel(II), copper(II), and zinc(II) solutions in a mixture of 50% (v/v) methanol and water. The magnitude of chelation between metal ions and ligand molecules was assessed by FT-IR, [...] Read more.
Three new transition-metal complexes were produced by refluxing azodicarbonamide (ADCA) with nickel(II), copper(II), and zinc(II) solutions in a mixture of 50% (v/v) methanol and water. The magnitude of chelation between metal ions and ligand molecules was assessed by FT-IR, UV, elemental analysis, TGA, conductivity, mass, and magnetic susceptibility measurements. FT-IR analysis suggested a bi-dentate chelation in all complexes, which takes place through the N-azo and O-carbonyl groups. Based on the measurement of magnetic moments and spectral analysis, a distorted octahedral geometry was proposed for Ni(II) and Cu(II) complexes, whereas zinc complex showed a hexa-coordinated geometry. The optical band gaps of the nickel(II), copper(II) and zinc(II) complexes were found to be 1.91, 2.50, and 1.96 eV, respectively, which means that they can be employed as semiconductors and that they are in the same range as highly effective photovoltaic materials. The Urbach energy parameters were also estimated from other optical parameters. The biological activity of azodicarbonamide and its synthesized complexes has been screened against the selected gram bacteria (+ve) and fungi. Full article
(This article belongs to the Special Issue Research about Vital Organic Chelates and Metal Ion Complexes Volume II)
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Review

Jump to: Research

17 pages, 13668 KiB  
Review
Imidazol(in)ium-2-Thiocarboxylate Zwitterion Ligands: Structural Aspects in Coordination Complexes
by David Elorriaga, Blanca Parra-Cadenas, Paula Pérez-Ramos, Raquel G. Soengas, Fernando Carrillo-Hermosilla and Humberto Rodríguez-Solla
Crystals 2023, 13(9), 1304; https://doi.org/10.3390/cryst13091304 - 26 Aug 2023
Viewed by 1432
Abstract
Azolium-2-thiocarboxylate zwitterion ligands have emerged as a promising class of compounds in the field of coordination chemistry due to their unique structural features and versatile applications. These ligands are characterized by a positively charged azolium ring and a negatively charged thiocarboxylate moiety, making [...] Read more.
Azolium-2-thiocarboxylate zwitterion ligands have emerged as a promising class of compounds in the field of coordination chemistry due to their unique structural features and versatile applications. These ligands are characterized by a positively charged azolium ring and a negatively charged thiocarboxylate moiety, making them capable of forming stable coordination complexes with various metal ions. One of the key structural aspects that make these ligands attractive for coordination chemistry is their ability to adopt diverse coordination modes with metal centers. The nature of these ligands enables them to engage in both monodentate and bidentate coordination, resulting in the formation of chelated complexes with enhanced stability and controlled geometry or the formation of polynuclear structures. This versatility in coordination behavior allows for the design of tailored ligands with specific metal-binding preferences, enabling the creation of unique and finely tuned coordination architectures. The azolium-2-thiocarboxylate zwitterionic ligands offer a promising platform for the design of coordination complexes with diverse structural architectures. Full article
(This article belongs to the Special Issue Research about Vital Organic Chelates and Metal Ion Complexes Volume II)
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