Special Issue "Polymorphism of Mechanochemically Synthesized Cocrystals"
Deadline for manuscript submissions: closed (25 March 2018)
During the last few years, mechanochemistry has emerged as a powerful method to form new structures by application of mechanical energy. In the simplest approach, a mortar and pestle are used to introduce solid transformations. Using automated milling devices, mechanochemical syntheses have become faster and more reliable. Mechanochemistry can produce solid forms, which are different to solution methods, without the need for miscible reactants. Therefore, the mechanochemical approach is now established as a green and efficient route for the formation of cocrystals and their polymorphs. Cocrystals are defined as multicomponent crystalline materials consisting of neutral molecules stabilized by non-covalent interactions, such as hydrogen bonds, π-π stacking, or halogen bonds. The cocrystallization of a compound with a suitable coformer can improve its physiochemical properties, such as solubility or stability, making it attractive for the development of new materials in pharmacy, agriculture, and explosives. The phenomenon of polymorphism is of great interest in academic and industrial research. Although polymorphs usually only differ slightly in energy, properties can change dramatically. Therefore, the control of polymorphism is of huge importance. The addition of liquids and polymers during grinding can influence the outcome of mechanochemical reactions. Mechanistic information is still sparse, making further research in the mechanochemical preparation of polymorphic cocrystals necessary.
Contributions in this Special issue cover, but are not limited to:
- Mechanochemical syntheses and characterization of cocrystals
- Transformation and stability of polymorphs
- Structure/property relationships of cocrystals
- Control of polymorphism during grinding: the role of solvent/additives in mechanochemical cocrystal formation
- Prediction and mechanism of cocrystal formations
Dr. Franziska Emmerling
Manuscript Submission Information
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