Editorial Board Members’ Collection Series: Recent Advancements of HPV Tumors of Head and Neck

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Head and Neck Oncology".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 2160

Special Issue Editors


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Guest Editor
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Interests: head and neck cancer; immunotherapy; clinical trial

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Guest Editor
Medical Oncology Unit, San Giovanni di Dio Hospital, 80027 Frattamaggiore, Naples, Italy
Interests: head and neck cancer; brain tumor; clinical research; chemotherapy; immunotherapy; target therapy; rare cancer; quality of life; patient centered care
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Special Issue Information

Dear Colleagues,

Although the incidence of smoking-related head and neck cancer (HNSCC) has been declining, that of HPV-mediated HNSCC has been consistently increasing globally for the past few decades, creating an increasing burden on the health system and posing a threat to otherwise healthy individuals. Although the majority of patients with HPV HNSCC are cured, the treatment-induced toxicity remains significant. For those with advanced disease, the treatment options are limited without major therapeutic breakthroughs since the introduction of anti-PD-1 immunotherapy. 

Thanks to our increasing understanding of the unique biology, along with unparalleled advances in molecular methodology and therapeutic modality, we are witnessing rapidly growing findings and expanding innovative diagnostic and therapeutic research to improve the survival and quality of life of patients with HPV HNSCC. 

In this Special Issue of recent advancements of HPV tumors of head and neck, we welcome original research or review articles on the wide range of topics related to HPV HNSCC, from epidemiology and biology to de-escalation strategies for locally advanced disease, plasma-based detection/surveillance of disease, and novel therapeutics, including HPV-targeting therapeutic vaccines or other novel biologic agents. 

Dr. Jong Chul Park
Dr. Raffaele Addeo
Guest Editors

Manuscript Submission Information

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Keywords

  • cancer biology
  • epidemiology
  • descalation therapy
  • serum-based HPV biomarker
  • novel investigational therapeutics
  • therapeutic vaccine

Published Papers (1 paper)

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12 pages, 301 KiB  
Perspective
Active Immune Phenotype in Head and Neck Cancer: Reevaluating the Iso-Effect Fractionation Based on the Linear Quadratic (LQ) Model—A Narrative Review
by Camil Ciprian Mireștean, Roxana Irina Iancu and Dragoș Petru Teodor Iancu
Curr. Oncol. 2023, 30(5), 4805-4816; https://doi.org/10.3390/curroncol30050362 - 8 May 2023
Cited by 1 | Viewed by 1655
Abstract
Altered fractionation concepts and especially moderate hypo-fractionation are evaluated as alternatives to standard treatment for head and neck squamous cell carcinoma (HNSCC), associated with or not concurrent with or sequential to chemotherapy. The calculation of the iso-equivalent dose regimens has as its starting [...] Read more.
Altered fractionation concepts and especially moderate hypo-fractionation are evaluated as alternatives to standard treatment for head and neck squamous cell carcinoma (HNSCC), associated with or not concurrent with or sequential to chemotherapy. The calculation of the iso-equivalent dose regimens has as its starting point the linear quadratic (LQ) formalism traditionally based on the “4Rs” of radiobiology. The higher rates of therapeutic failure after radiotherapy of HNSCC are associated with the heterogeneity of radio-sensibility. The identification of genetic signatures and radio-resistance scores aims to improve the therapeutic ratio of radiotherapy and to conceptualize personalized fractionation schemes. The new data regarding the involvement of the sixth “R” of radiobiology in HNSCC, especially for the HPV-driven subtype, but also for the “immune active” minority of HPV-negative HNSCCs, bring to the fore a multifactorial variation of the α/β ratio. The involvement of the antitumor immune response and the dose/fractionation/volume factors as well as the therapeutic sequence in the case of new multimodal treatments including immune checkpoint inhibitors (ICIs) could be included as an additional term in the quadratic linear formalism especially for hypo-fractionation regimens. This term should take into account the dual immunomodulatory effect (immunosuppressant and stimulator of antitumor immunity) of radiotherapy, which varies from case to case and can bring benefit or a detrimental effect. Full article
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