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Diagnostics
Special Issues
Advances in Diagnosis and Treatment of Colorectal Cancer
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Advances in Diagnosis and Treatment of Colorectal Cancer

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1011

Special Issue Editor

Dr. George Pappas-Gogos

E-Mail Website
Guest Editor
1. Hepatobiliary and Pancreatic Surgery (HPB) Unit, Department of Surgery, University Hospital of Ioannina and Faculty of Medicine, School of Health Sciences, University of Ioannina, 451 10 Ioannina, Greece
2. Second Department of Surgery, General University Hospital of Alexandroupolis and Medical School, Democritus University of Thrace, 691 00 Alexandroupoli, Greece
Interests: colorectal cancer; surgery; endoscopy; laparoscopic

Special Issue Information

Dear Colleagues,

Colorectal cancer (CRC) is a common gastrointestinal cancer that has a high mortality rate, posing a serious threat to human health. Many CRCs are caused by the malignant transformation of colorectal polyps. Therefore, early diagnosis and treatment are generally considered to be the most effective ways to reduce CRC mortality.

This Special Issue aims to improve our knowledge of recent advances in the diagnosis and treatment of CRC. Submissions may include articles reporting on current original research, experimental methodology, and the introduction of new devices and review articles summarizing the current status of biomarkers or images for pathologic diagnosis and management of CRC. I look forward to receiving your contributions.

Dr. George Pappas-Gogos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colorectal cancer
  • imaging diagnosis
  • endoscopy
  • pathology diagnosis
  • epidemiology
  • prediction
  • prognosis

Published Papers (1 paper)

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Research

11 pages, 1662 KiB  
Article
Clinicopathological Significances of Peritumoral Budding in Colorectal Cancer: A Detailed Analysis Based on Mucinous and Micropapillary Pattern
by Jung-Soo Pyo, Nae Yu Kim, Kyueng-Whan Min and Dong-Wook Kang
Diagnostics 2023, 13(23), 3564; https://doi.org/10.3390/diagnostics13233564 - 29 Nov 2023
Viewed by 733
Abstract
The present study aimed to evaluate the correlations between peritumoral tumor budding (PTB) and the clinicopathological characteristics of colorectal cancer (CRC) according to histological components. The PTBs were investigated and divided into high and low groups. The clinicopathological significance and prognostic implications of [...] Read more.
The present study aimed to evaluate the correlations between peritumoral tumor budding (PTB) and the clinicopathological characteristics of colorectal cancer (CRC) according to histological components. The PTBs were investigated and divided into high and low groups. The clinicopathological significance and prognostic implications of PTB in CRC were evaluated. High PTB was found in 104 of 266 CRCs (39.1%). High PTB was significantly correlated with left-sided tumors, lymphatic invasion, lymph node metastasis, distant metastasis, and high pTNM stage. However, there was no significant correlation between PTB and the other clinicopathological characteristics. PTB was significantly higher in CRCs without the mucinous component than those with the mucinous component (p = 0.008). However, there was no significant difference between CRCs with and without the micropapillary pattern (p = 0.123). Patients with high PTB had worse recurrence-free survival than those with low PTB (p = 0.031). In the subgroup analysis based on histological components, a significant correlation between PTB and recurrence-free survival was found in CRC with a micropapillary pattern but not in those without a micropapillary pattern (p = 0.010 and p = 0.178, respectively). These findings indicate that high PTB is significantly correlated with aggressive tumor behaviors and worse survival in patients with CRC. However, the prognostic implications of PTB can differ according to histological components. Full article
(This article belongs to the Special Issue Advances in Diagnosis and Treatment of Colorectal Cancer)
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