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Diagnostics
Special Issues
Precision Strategies to Improve Diagnosis and Prognosis in Gastrointestinal Disease
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Precision Strategies to Improve Diagnosis and Prognosis in Gastrointestinal Disease

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 1109

Special Issue Editors

Dr. Manuel Barberio

E-Mail Website
Guest Editor
1. Institute for Research against Digestive Cancer (IRCAD), 67091 Strasbourg, France
2. Department of General Surgery, Hospital Card. G. Panico, 73039 Tricase, Italy
Interests: optical imaging; image-guided surgery; surgical innovation; robotic surgery; machine learning and hyperspectral imaging
Special Issues, Collections and Topics in MDPI journals
Dr. Deborah S. Keller

E-Mail Website
Guest Editor
Department of Surgery, Division of Colorectal Surgery, Lankenau Medical Center, Wynnewood, PA, USA
Interests: surgical innovation; imaging biomarkers; developing standards for colorectal cancer delivery
Dr. Massimo Giuseppe Viola

E-Mail Website
Guest Editor
Department of General Surgery, Hospital Card. G. Panico, 73039 Tricase, Italy
Interests: hepatobiliopancreatic surgery; colorectal surgery; upper-GI surgery; oncological surgery; gastrointestinal surgery; ERAS protocol; minimally invasive surgery; robotic surgery; optical imaging; fluorescence-guided imaging; hyperspectral imaging
Dr. Mahdi Al-Taher

E-Mail Website
Guest Editor
1. Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
2. Research Institute against Digestive Cancer (IRCAD), Strasbourg, France
Interests: optical imaging; image-guided surgery; surgical innovation; robotic surgery; machine learning and hyperspectral imaging; colorectal surgery
Dr. Filippo Carannante

E-Mail Website
Guest Editor
Unit of Colorectal Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 00128 Roma, Italy
Interests: abdominal surgery; minimally invasive surgery; colorectal surgery; colorectal cancer; IBD; image-guided surgery; rectal functional disorders; ERAS
Dr. Marco Caricato

E-Mail Website
Guest Editor
Unit of Colorectal Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 00128 Roma, Italy
Interests: abdominal surgery; minimally invasive surgery; colorectal surgery; colorectal cancer; IBD; image-guided surgery; rectal functional disorders; ERAS

Special Issue Information

Dear Colleagues,

The diagnosis and prognosis of gastrointestinal disease have undergone major advances over the last 25 years, with enhancements in chemotherapeutic agents, patient optimization strategies, novel operative techniques and minimally invasive surgery platforms. These changes have led to dramatic improvements in oncologic and functional outcomes, as well as in the quality of life of patients. Despite these advances, there remains a need to increase the accuracy and precision of the diagnosis and prognosis of gastrointestinal disease, especially in gastrointestinal cancer cases. The integration of innovative technologies during preoperative staging and in the operating room during procedures addresses these needs. Robust preclinical research is ongoing to help determine the most sensitive and specific biomarkers to distinguish malignant disease from normal surrounding tissue. Also of note is the clinical application of innovative image-guided surgery techniques, which permits the development of predictive algorithms and real-time advanced vision in the operating room. These exciting new technologies may translate to safer and more efficient surgical planning, surgical procedures, and patient outcomes. In this Special Issue, we present original work on the novel preclinical and clinical technologies, operative techniques, and perioperative management strategies that are being developed and applied to increase precision diagnosis and prognosis in gastrointestinal cases. Introducing the current state and future goals for these new tools from experts in the field will provide readers with an understanding of those innovative tools, their application, and their potential in gastrointestinal surgery.

Dr. Manuel Barberio
Dr. Deborah S. Keller
Dr. Massimo Giuseppe Viola
Dr. Mahdi Al-Taher
Dr. Filippo Carannante
Dr. Marco Caricato
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diagnosis and prognosis
  • gastrointestinal disease
  • robotic surgery
  • new technologies
  • image-guided fluorescence
  • surgical innovation
  • precision surgery

Published Papers (1 paper)

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Research

16 pages, 2520 KiB  
Article
Analysis of Predictors and Risk Factors of Postpolypectomy Syndrome
by Stefano Fusco, Michelle E. Bauer, Ulrike Schempf, Dietmar Stüker, Gunnar Blumenstock, Nisar P. Malek, Christoph R. Werner and Dörte Wichmann
Diagnostics 2024, 14(2), 127; https://doi.org/10.3390/diagnostics14020127 - 05 Jan 2024
Viewed by 833
Abstract
Background and aims: Postpolypectomy syndrome (PPS) is a relevant adverse event that can appear after polypectomy. Several publications mention postpolypectomy syndrome using different criteria to define it. The aim of this study is to detect potential risk factors and predictors for developing PPS [...] Read more.
Background and aims: Postpolypectomy syndrome (PPS) is a relevant adverse event that can appear after polypectomy. Several publications mention postpolypectomy syndrome using different criteria to define it. The aim of this study is to detect potential risk factors and predictors for developing PPS and to define the main criteria of PPS. Methods: In this retrospective monocentric study, 475 out of 966 patients who underwent colonoscopy with polypectomy from October 2015 to June 2020 were included. The main criterion of PPS is defined as the development of postinterventional abdominal pain lasting more than six hours. Results: A total of 9.7% of the patients developed PPS, which was defined as local abdominal pain around the polypectomy area after six hours. A total of 8.6% of the study population had abdominal pain within six hours postintervention. A total of 3.7% had an isolated triad of fever, leukocytosis, and increased CRP in the absence of abdominal pain. Increased CRP combined with an elevated temperature over 37.5 °C seems to be a positive predictor for developing PPS. Four independent risk factors could be detected: serrated polyp morphology, polypoid configurated adenomas, polyp localization in the cecum, and the absence of intraepithelial neoplasia. Conclusions: Four independent risk factors for developing PPS were detected. The combination of increased CRP levels with elevated temperature seems to be a predictor for this pathology. As expected, the increasing use of cold snare polypectomies will reduce the incidence of this syndrome. Key summary: Our monocentric study on 966 patients detected four independent risk factors for developing PPS: pedunculated polyp, resected polyps in the cecum, absence of IEN, and serrated polyp morphology. The combination of increased CRP levels with elevated temperature seems to be a predictor for this pathology. Full article
(This article belongs to the Special Issue Precision Strategies to Improve Diagnosis and Prognosis in Gastrointestinal Disease)
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