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Diagnostics
Special Issues
Diagnosis and Management of Non-malignant Hematological Disease
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Diagnosis and Management of Non-malignant Hematological Disease

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 1547

Special Issue Editor

Dr. Laura Pistoia

E-Mail Website
Guest Editor
1. Department of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy
2. Clinical Research Unit, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy
Interests: blood disorders; cardiac magnetic resonance imaging; clinical research; molecular biology

Special Issue Information

Dear Colleagues,

Hematological diseases encompass a wide range of conditions that can significantly impact an individual's health and quality of life. Better diagnostic criteria, differential diagnosis markers, risk stratification, accurate monitoring, and prognostic definition are crucial to improve the identification and treatment of disorders related to blood and blood-forming tissues.

This Special Issue aims to collect new advances in this field, with a focus on the characterization and management of non-malignant hematological conditions, in order to improve clinical care and quality of life of hematological patients.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) diagnostic techniques, treatment modalities, long term monitoring, supportive care, prognosis and outcomes.

I look forward to receiving your contributions.

Dr. Laura Pistoia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • thalassemia
  • sickle cell disease
  • hemochromatosis
  • aplastic anemia
  • myelodysplastic syndrome
  • bone marrow transplantation
  • genetic screening
  • blood transfusions
  • magnetic resonance imaging

Published Papers (1 paper)

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Research

15 pages, 867 KiB  
Article
Low Vitamin D Levels Are Associated with Increased Cardiac Iron Uptake in Beta-Thalassemia Major
by Antonella Meloni, Laura Pistoia, Cristina Vassalle, Anna Spasiano, Ilaria Fotzi, Sergio Bagnato, Maria Caterina Putti, Antonella Cossu, Francesco Massei, Piera Giovangrossi, Silvia Maffei, Vincenzo Positano and Filippo Cademartiri
Diagnostics 2023, 13(24), 3656; https://doi.org/10.3390/diagnostics13243656 - 13 Dec 2023
Cited by 1 | Viewed by 1351
Abstract
We evaluated the association of vitamin D and parathormone (PTH) levels with cardiac iron and function in beta-thalassemia major (β-TM) patients. Two-hundred and seventy-eight TM patients (39.04 ± 8.58 years, 56.8% females) underwent magnetic resonance imaging for the assessment of iron overload (T2* [...] Read more.
We evaluated the association of vitamin D and parathormone (PTH) levels with cardiac iron and function in beta-thalassemia major (β-TM) patients. Two-hundred and seventy-eight TM patients (39.04 ± 8.58 years, 56.8% females) underwent magnetic resonance imaging for the assessment of iron overload (T2* technique), biventricular function parameters (cine images), and replacement myocardial fibrosis (late gadolinium enhancement technique). Vitamin D levels were deficient (<20 ng/dL) in 107 (38.5%) patients, insufficient (20–30 ng/dL) in 96 (34.5%) patients, and sufficient (≥30 ng/dL) in 75 (27.0%) patients. Deficient vitamin D patients had a significantly higher frequency of myocardial iron overload (MIO; global heart T2* < 20 ms) than patients with sufficient and insufficient vitamin D levels and a significantly higher left ventricular end-diastolic volume index and mass index than patients with sufficient vitamin D levels. PTH was not associated with cardiac iron, function, or fibrosis. In the multivariate regression analysis, vitamin D, serum ferritin, and pancreatic iron levels were the strongest predictors of global heart T2* values. In receiver operating characteristic curve analysis, a vitamin D level ≤ 17.3 ng/dL predicted MIO with a sensitivity of 81.5% and a specificity of 75.3% (p < 0.0001). In TM, the periodic and regular assessment of vitamin D levels can be beneficial for the prevention of cardiac iron accumulation and subsequent overt dysfunction. Full article
(This article belongs to the Special Issue Diagnosis and Management of Non-malignant Hematological Disease)
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