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Diagnostics
Special Issues
Structure–Function Relationship in Retinal Diseases, Second Edition
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Structure–Function Relationship in Retinal Diseases, Second Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 1992

Special Issue Editors

Dr. Benedetto Falsini

E-Mail Website
Guest Editor
1. Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
2. Ophthalmology Unit, Catholic University “Sacro Cuore”, 00168 Rome, Italy
Interests: ophthalmology; oct angiography; retinal; age-related macular degeneration; degenerative retinal diseases; retina; pathologies
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Andrea Cusumano

E-Mail Website
Guest Editor
Department of Ophthalmology, Tor Vergata University, 00133 Rome, Italy
Interests: retina; ophthalmology; ultrastructural analysis; laser techniques; hereditary retinal diseases

Special Issue Information

Dear Colleagues,

Therapies for degenerative retinal diseases are rapidly evolving toward personalized or precision medicines, the aim of which is to stop or reverse the degenerative process by targeting its molecular mechanisms. In order to optimize this approach, it is essential to evaluate in detail the relationships between the structure and function of the retina in different pathologies.

This Special Issue aims to examine the correlations (or absence thereof) between the retinal structure and function in degenerative diseases of the retina, from animal models to clinical practice. This approach has important implications for expressing the maximum therapeutic potential of emerging treatments based on personalized medicine.

Dr. Benedetto Falsini
Prof. Dr. Andrea Cusumano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • degenerative retinal diseases
  • structure and function of the retina
  • retina pathologies
  • personalized medicine
  • precision medicines
  • molecular mechanisms

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Published Papers (2 papers)

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Research

16 pages, 6129 KiB  
Article
Development of an Innovative Pupillometer Able to Selectively Stimulate the Eye’s Fundus Photoreceptor Cells
by Giovanni Gibertoni, Anton Hromov, Filippo Piffaretti and Martial H. Geiser
Diagnostics 2024, 14(17), 1940; https://doi.org/10.3390/diagnostics14171940 - 2 Sep 2024
Viewed by 614
Abstract
Recent advancements in clinical research have identified the need to combine pupillometry with a selective stimulation of the eye’s photoreceptor cell types to broaden retinal and neuroretinal health assessment opportunities. Our thorough analysis of the literature revealed the technological gaps that currently restrict [...] Read more.
Recent advancements in clinical research have identified the need to combine pupillometry with a selective stimulation of the eye’s photoreceptor cell types to broaden retinal and neuroretinal health assessment opportunities. Our thorough analysis of the literature revealed the technological gaps that currently restrict and hinder the effective utilization of a method acknowledged to hold great potential. The available devices do not adequately stimulate the photoreceptor types with enough contrast and do not guarantee seamless device function integration, which would enable advanced data analysis. RetinaWISE is an advanced silencing pupillometry device that addresses these deficiencies. It combines a Maxwellian optical arrangement with advanced retinal stimulation, allowing for calibrated standard measurements to generate advanced and consistent results across multiple sites. The device holds a Class 1 CE marking under EU regulation 2017/745, thus facilitating clinical research progress. Full article
(This article belongs to the Special Issue Structure–Function Relationship in Retinal Diseases, Second Edition)
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13 pages, 2780 KiB  
Article
Functional and Morphological Outcomes after Trabeculectomy and Deep Sclerectomy—Results from a Monocentric Registry Study
by Valentin Pfeiffer, Pascal Aurel Gubser, Xiao Shang, Joel-Benjamin Lincke, Nathanael Urs Häner, Martin Sebastian Zinkernagel and Jan Darius Unterlauft
Diagnostics 2024, 14(1), 101; https://doi.org/10.3390/diagnostics14010101 - 2 Jan 2024
Viewed by 974
Abstract
The aim of this study was to compare the effectiveness of trabeculectomy (TE) and deep sclerectomy (DS) in lowering intraocular pressure (IOP) and thereby preserving visual field and peripapillary retinal nerve fiber layer (RNFL) tissue in primary open-angle glaucoma (POAG) cases. IOP, number [...] Read more.
The aim of this study was to compare the effectiveness of trabeculectomy (TE) and deep sclerectomy (DS) in lowering intraocular pressure (IOP) and thereby preserving visual field and peripapillary retinal nerve fiber layer (RNFL) tissue in primary open-angle glaucoma (POAG) cases. IOP, number of IOP-lowering medications, visual acuity, mean defect of standard automated perimetry, and mean peripapillary RNFL thickness were retrospectively collected and followed up for 3 years after surgery. TE was performed in 104 eyes and DS in 183 eyes. Age, gender, laterality, IOP, number of medications, visual acuity, perimetry mean defect, and peripapillary RNFL thickness were equally distributed at baseline. Mean IOP decreased from 23.8 ± 1.4 mmHg and 23.1 ± 0.4 mmHg to 13.4 ± 0.6 mmHg (p < 0.001) and 15.4 ± 0.7 mmHg (p = 0.001) in the TE and DS groups, respectively. Mean defect remained stable (TE: −11.5 ± 0.9 dB to −12.0 ± 1.1 (p = 0.090); DS: −10.5 ± 0.9 dB to −11.0 ± 1.0 dB (p = 0.302)), while mean peripapillary RNFL thickness showed further deterioration during follow-up (TE group: 64.4 ± 2.1 μm to 59.7 ± 3.5 μm (p < 0.001); DS group: 64.9 ± 1.9 μm to 58.4 ± 2.1 μm (p < 0.001)). Both TE and DS were comparably effective concerning postoperative reduction in IOP and medication. However, glaucoma disease further progressed during follow-up. Full article
(This article belongs to the Special Issue Structure–Function Relationship in Retinal Diseases, Second Edition)
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