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Special Issue Editor

Dr. Darren Shu Jeng Ting

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Guest Editor

1. Academic Unit of Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK
2. Birmingham and Midland Eye Centre, Birmingham, UK
Interests: antimicrobial therapy; antimicrobial resistance; artificial intelligence; corneal disease; drug discovery and development; host defense peptide; infectious keratitis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue presents an exciting opportunity for ophthalmologists and vision science researchers to publish their innovative work on the diagnosis and management of corneal diseases, including corneal infection, corneal dystrophy, dry eye, ocular surface diseases, corneal transplantations, and others. Potential areas include, but are not limited to: diagnosis, pathology, related biomarkers, medical imaging, optical imaging, artificial intelligence, novel medical therapeutics, and surgical interventions. We intend to establish a collection of excellent publications around this theme and provide a venue for networking and communication between scholars in the field concerned with novel methods for the diagnosis and management of various corneal diseases. We have the pleasure to invite you to submit your work to this Special Issue on “Advances in Diagnosis and Treatment of Corneal Diseases". Original research articles (either clinical or basic science research), reviews, short communications and interesting images are welcome. All papers will be fully open access upon publication after peer review.

Dr. Darren Shu Jeng Ting
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

corneal diseases
corneal infection
corneal dystrophy
dry eye
ocular surface diseases
corneal transplantations
diagnosis
pathology
biomarkers
medical imaging
optical imaging
artificial intelligence
novel medical therapeutics
surgical interventions

Published Papers (2 papers)

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Research

Jump to: Review

18 pages, 10317 KiB

Open AccessArticle

Reduced Retinal Blood Vessel Densities Measured by Optical Coherence Tomography Angiography in Keratoconus Patients Are Negatively Correlated with Keratoconus Severity

by Martin Dominik Leclaire, Jens Julian Storp, Larissa Lahme, Eliane Luisa Esser, Nicole Eter and Maged Alnawaiseh

Diagnostics 2024, 14(7), 707; https://doi.org/10.3390/diagnostics14070707 - 27 Mar 2024

Viewed by 575

Abstract

Keratoconus (KC) is the most common corneal ectasia. Optical coherence tomography angiography (OCT-A) is a relatively new non-invasive imaging technique that allows the visualization and quantification of retinal and choriocapillary blood vessels. The aim of this study is to assess retinal and choriocapillary vessel density (VD) differences between KC patients and healthy controls and to investigate correlations between VD and KC severity. Fifty-two eyes were included in this exploratory study: twenty-six eyes from 26 KC patients and twenty-six eyes from 26 age- and gender-matched healthy controls. All patients underwent Scheimpflug corneal topography with Pentacam, axis lengths measurement and optical coherence tomography angiography (OCT-A). The thinnest spot in corneal pachymetry, maximum K (Kmax) and KC severity indices from the Belin/Ambrósio enhanced ectasia display (BAD) were also assessed. There was a distinct reduction particularly in the retinal VD of the superficial capillary plexus (SCP). Correlation analyses showed strong and moderate negative correlations between the VD in the macular SCP and BAD KC scores and between the SCP VD and Kmax. There was no difference in retinal thickness between the KC and healthy controls. With this study, further evidence for altered VD measurements by OCT-A in KC patients is given. For the first time, we demonstrated negative correlations between BAD KC scores and retinal blood vessel alterations. A major limitation of the study is the relatively small sample size. Since an artefactual reduction of the quantitative OCT-A measurements due to irregular corneal topography in KC must be assumed, it remains to be investigated whether there are also actual changes in the retinal microcirculation in KC. Full article

(This article belongs to the Special Issue Advances in Diagnosis and Treatment of Corneal Diseases)

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Review

Jump to: Research

27 pages, 11959 KiB

Open AccessReview

Clinical Applications of Anterior Segment Optical Coherence Tomography: An Updated Review

by Yu Jeat Chong, Matthew Azzopardi, Gulmeena Hussain, Alberto Recchioni, Jaishree Gandhewar, Constantinos Loizou, Ioannis Giachos, Ankur Barua and Darren S. J. Ting

Diagnostics 2024, 14(2), 122; https://doi.org/10.3390/diagnostics14020122 - 05 Jan 2024

Viewed by 1314

Abstract

Since its introduction, optical coherence tomography (OCT) has revolutionized the field of ophthalmology and has now become an indispensable, noninvasive tool in daily practice. Most ophthalmologists are familiar with its use in the assessment and monitoring of retinal and optic nerve diseases. However, it also has important applications in the assessment of anterior segment structures, including the cornea, conjunctiva, sclera, anterior chamber, and iris, and has the potential to transform the clinical examination of these structures. In this review, we aim to provide a comprehensive overview of the potential clinical utility of anterior segment OCT (AS-OCT) for a wide range of anterior segment pathologies, such as conjunctival neoplasia, pterygium, scleritis, keratoconus, corneal dystrophies, and infectious/noninfectious keratitis. In addition, the clinical applications of AS-OCT (including epithelial mapping) in preoperative planning and postoperative monitoring for corneal and refractive surgeries are discussed. Full article

(This article belongs to the Special Issue Advances in Diagnosis and Treatment of Corneal Diseases)

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