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Diagnostics
Special Issues
Pathological and Molecular Diagnosis of Melanoma
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Pathological and Molecular Diagnosis of Melanoma

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 591

Special Issue Editor

Dr. Alexander Birbrair

E-Mail Website
Guest Editor
Department of Dermatology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA
Interests: melanoma; tumor microenvironment; niche; sensory neurons; glial cells; stem cells; pericytes; metastasis; dormancy

Special Issue Information

Dear Colleagues,

This Special Issue aims to collect high-quality scientific papers that deepen our understanding of the clinical, histopathological and molecular characteristics of melanoma, potentially correlating them with the diagnosis and prognosis of melanoma patients.

Dr. Alexander Birbrair
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pathological
  • molecular diagnosis
  • melanoma

Published Papers (1 paper)

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Review

19 pages, 421 KiB  
Review
Pathological and Molecular Diagnosis of Uveal Melanoma
by Mihai Adrian Păsărică, Paul Filip Curcă, Christiana Diana Maria Dragosloveanu, Alexandru Călin Grigorescu and Cosmin Ionuț Nisipașu
Diagnostics 2024, 14(9), 958; https://doi.org/10.3390/diagnostics14090958 - 02 May 2024
Viewed by 349
Abstract
(1) Background: Uveal melanoma (UM) is a common malignant intraocular tumor that presents with significant genetic differences to cutaneous melanoma and has a high genetic burden in terms of prognosis. (2) Methods: A systematic literature search of several repositories on uveal melanoma diagnosis, [...] Read more.
(1) Background: Uveal melanoma (UM) is a common malignant intraocular tumor that presents with significant genetic differences to cutaneous melanoma and has a high genetic burden in terms of prognosis. (2) Methods: A systematic literature search of several repositories on uveal melanoma diagnosis, prognosis, molecular analysis, and treatment was conducted. (3) Results: Recent genetic understanding of oncogene-initiation mutations in GNAQ, GNA11, PLCB4, and CYSLTR2 and secondary progression drivers of BAP1 inactivation and SF3B1 and EIF1AX mutations offers an appealing explanation to the high prognostic impact of adding genetic profiling to clinical UM classification. Genetic information could help better explain peculiarities in uveal melanoma, such as the low long-term survival despite effective primary tumor treatment, the overwhelming propensity to metastasize to the liver, and possibly therapeutic behaviors. (4) Conclusions: Understanding of uveal melanoma has improved step-by-step from histopathology to clinical classification to more recent genetic understanding of oncogenic initiation and progression. Full article
(This article belongs to the Special Issue Pathological and Molecular Diagnosis of Melanoma)
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