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Diagnostics
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Optical Coherence Tomography (OCT) Imaging in Ophthalmology
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Optical Coherence Tomography (OCT) Imaging in Ophthalmology

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Optical Diagnostics".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 2423

Special Issue Editors

Prof. Dr. Jan Darius Unterlauft

E-Mail Website
Guest Editor
Department of Ophthalmology, Inselspital, University of Bern, Freiburgstrasse 15, 3010 Bern, Switzerland
Interests: glaucoma; glaucoma surgery; neuroprotection; retinal imaging; optic nerve head imaging
Special Issues, Collections and Topics in MDPI journals
Dr. Somar M. Hasan

E-Mail Website
Guest Editor
Ophthalmology Department, Jena University Hospital, 07743 Jena, Germany
Interests: glaucoma; glaucoma diagnosis; glaucoma surgery; MIGS; bleb; filtering glaucoma surgery

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to this Special Issue of Diagnostics titled “Optical Coherence Tomography (OCT) Imaging in Ophthalmology”. OCT imaging has become a central part of diagnostics in ophthalmology over the past few years. Continuous technical advancements now facilitate the near-histological-quality examination of eye tissues in vivo. Clinically, OCT imaging is used to screen for existing pathological changes of various different tissues (i.e., macula, optic nerve head, cornea). Apart from this, OCT imaging techniques can be utilized to gain further insights into cellular mechanisms taking place during disease progression. The aim of this Special Issue is to provide an overview of recent developments in the field of clinical and experimental OCT imaging in ophthalmology, and to illustrate potential further developments in the future. Therefore, in this Special Issue we welcome the submission of original research articles as well as reviews dealing with the diverse possible applications of OCT imaging in the field of ophthalmology.

We are looking forward to receiving your contributions.

Prof. Dr. Jan Darius Unterlauft
Dr. Somar M. Hasan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ophthalmology
  • Optical Coherence Tomography
  • OCT
  • glaucoma
  • retina
  • cornea
  • lens
  • imaging

Published Papers (2 papers)

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Research

8 pages, 610 KiB  
Article
Clinical Evaluation of a New Spectral-Domain Optical Coherence Tomography-Based Biometer
by Jorge L. Alió, Marina José-Martínez, Antonio Martínez-Abad, Alejandra E. Rodríguez, Francesco Versaci, Jesper Hjortdal, Joaquim Neto Murta, Ana B. Plaza-Puche, Mario Cantó-Cerdán and David P. Piñero
Diagnostics 2024, 14(5), 560; https://doi.org/10.3390/diagnostics14050560 - 06 Mar 2024
Viewed by 596
Abstract
The VEMoS-AXL system is a new optical biometer based on spectral domain optical coherence tomography (SD-OCT) that has been tested in terms of intrasession repeatability and compared with a swept-source optical coherence tomography biometer (SS-OCT), which is recognized as the gold standard for [...] Read more.
The VEMoS-AXL system is a new optical biometer based on spectral domain optical coherence tomography (SD-OCT) that has been tested in terms of intrasession repeatability and compared with a swept-source optical coherence tomography biometer (SS-OCT), which is recognized as the gold standard for the performance of an agreement analysis. A biometric analysis was performed three consecutive times in 120 healthy eyes of 120 patients aged between 18 and 40 years with the SD-OCT system, and afterwards, a single measurement was obtained with the SS-OCT system. Within-subject standard deviations were 0.004 mm, 4.394 µm, and 0.017 mm for axial length (AL), central corneal thickness (CCT), and anterior chamber depth (ACD) measures obtained with the SD-OCT biometer, respectively. The agreement between devices was good for AL (limits of agreement, LoA: −0.04 to 0.03 mm) and CCT (LoA: −4.36 to 14.38 µm), whereas differences between devices were clinically relevant for ACD (LoA: 0.03 to 0.21 mm). In conclusion, the VEMoS-AXL system provides consistent measures of anatomical parameters, being most of them interchangeable with those provided by the SS-OCT-based gold standard. Full article
(This article belongs to the Special Issue Optical Coherence Tomography (OCT) Imaging in Ophthalmology)
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12 pages, 928 KiB  
Article
A Comparative Analysis of Morphology and Dimensions of Functional Blebs following PRESERFLO-Microshunt and XEN-Gel-Stent, a Study Using Anterior Segment OCT
by Somar M. Hasan, Theresa Theilig, Menelaos Papadimitriou and Daniel Meller
Diagnostics 2023, 13(14), 2318; https://doi.org/10.3390/diagnostics13142318 - 09 Jul 2023
Cited by 1 | Viewed by 1132
Abstract
Evaluation of bleb morphology is a vital part of successful filtration glaucoma surgery. The PRESERFLO-MicroShunt (PRESERFLO) and XEN-Gel-Stent (XEN) are drainage devices implanted using different surgical approaches (ab externo and ab interno, respectively), potentially resulting in distinct bleb morphology. Understanding these morphological differences [...] Read more.
Evaluation of bleb morphology is a vital part of successful filtration glaucoma surgery. The PRESERFLO-MicroShunt (PRESERFLO) and XEN-Gel-Stent (XEN) are drainage devices implanted using different surgical approaches (ab externo and ab interno, respectively), potentially resulting in distinct bleb morphology. Understanding these morphological differences is essential for postoperative care. In this study, we retrospectively examined functioning blebs following PRESERFLO and XEN implantation using high-resolution anterior segment OCT imaging. Qualitative assessment utilizing the Jenaer Bleb Grading System and quantitative assessment measuring 12 parameters representing bleb dimensions were conducted, and the results were compared between the two groups. A total of 80 eyes from 80 patients were included (41 after PRESERFLO, 39 after XEN). Functioning blebs following PRESERFLO exhibited a higher frequency of hyperreflective tenon changes compared to XEN (31.7% vs. 10.3%, respectively, p = 0.02) and a lower frequency of cavernous changes (17.1% vs. 35.9%, p = 0.05). Additionally, PRESERFLO blebs showed a higher frequency of visible episcleral lakes (92.7% vs. 30.8%, p < 0.001). Furthermore, PRESERFLO blebs demonstrated larger height (2.13 ± 0.5 vs. 1.85 ± 0.6 mm, p = 0.03), width (10.31 ± 2.3 vs. 9.1 ± 2.3 mm, p = 0.02), length (9.13 ± 1.8 vs. 8.24 ± 1.9 mm, p = 0.04), posterior location relative to the limbus (6.21 ± 1.2 vs. 5.21 ± 1.8 mm, p = 0.005), and a thicker bleb wall (1.60 ± 0.5 vs. 1.1 ± 0.4 mm, p = 0.004). Functioning blebs following PRESERFLO and XEN displayed morphological distinctions, likely attributed to variations in surgical techniques (ab externo vs. ab interno) and stent dimensions. These morphological differences should be taken into consideration when evaluating blebs, as they could impact assessments of bleb functionality and influence decisions regarding postoperative interventions. Full article
(This article belongs to the Special Issue Optical Coherence Tomography (OCT) Imaging in Ophthalmology)
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