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Diagnostics
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Advances in the Diagnostics and Therapies of Glioma
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Advances in the Diagnostics and Therapies of Glioma

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (25 March 2023) | Viewed by 1718

Special Issue Editor

Dr. Giuseppe La Rocca

E-Mail Website
Guest Editor
Department of Neurosurgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS and Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Interests: brain and spine tumors; degenerative spine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gliomas are one of the most common types of primary nervous system tumors. Despite multidisciplinary approaches and technological advances, the treatment of gliomas remains a challenge. Significant progress has been made in the development of surgical approaches, innovative imaging techniques, molecular characterization, and adjuvant radiation therapy. Intraoperative neuromonitoring and neuronavigation as well as metabolic navigation could also help neurosurgeons during tumor removal. However, the extent of resection has a fundamental role in the management of gliomas because of the diffuse infiltration into the surrounding brain parenchyma. Moreover, demarcation between tumor and normal brain parenchyma is always challenging.
Neurosurgery has experienced significant improvements in the management of most of the diseases in the last few years, but despite these efforts the management of glioma is still far from an acceptable prognosis. Therefore, an update of current surgical strategies together with tumor biology as well as multidisciplinary approaches could improve the overall survival of these patients.

In this Research Topic, we welcome original research and review articles focusing on updated diagnostic patterns, surgical strategies and innovative multidisciplinary treatment protocols

Dr. Giuseppe La Rocca
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glioma 
  • neuro-oncology 
  • surgery 
  • surgical techniques 
  • brain 
  • neurosurgery

Published Papers (1 paper)

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Research

9 pages, 765 KiB  
Article
Timing of Early Postoperative MRI following Primary Glioblastoma Surgery—A Retrospective Study of Contrast Enhancements in 311 Patients
by Alexander Malcolm Rykkje, Vibeke Andrée Larsen, Jane Skjøth-Rasmussen, Michael Bachmann Nielsen, Jonathan Frederik Carlsen and Adam Espe Hansen
Diagnostics 2023, 13(4), 795; https://doi.org/10.3390/diagnostics13040795 - 20 Feb 2023
Cited by 3 | Viewed by 1415
Abstract
An early postoperative MRI is recommended following Glioblastoma surgery. This retrospective, observational study aimed to investigate the timing of an early postoperative MRI among 311 patients. The patterns of the contrast enhancement (thin linear, thick linear, nodular, and diffuse) and time from surgery [...] Read more.
An early postoperative MRI is recommended following Glioblastoma surgery. This retrospective, observational study aimed to investigate the timing of an early postoperative MRI among 311 patients. The patterns of the contrast enhancement (thin linear, thick linear, nodular, and diffuse) and time from surgery to the early postoperative MRI were recorded. The primary endpoint was the frequencies of the different contrast enhancements within and beyond the 48-h from surgery. The time dependence of the resection status and the clinical parameters were analysed as well. The frequency of the thin linear contrast enhancements significantly increased from 99/183 (50.8%) within 48-h post-surgery to 56/81 (69.1%) beyond 48-h post-surgery. Similarly, MRI scans with no contrast enhancements significantly declined from 41/183 (22.4%) within 48-h post-surgery to 7/81 (8.6%) beyond 48-h post-surgery. No significant differences were found for the other types of contrast enhancements and the results were robust in relation to the choice of categorisation of the postoperative periods. Both the resection status and the clinical parameters were not statistically different in patients with an MRI performed before and after 48 h. The findings suggest that surgically induced contrast enhancements are less frequent when an early postoperative MRI is performed earlier than 48-h, supporting the recommendation of a 48-h window for an early postoperative MRI. Full article
(This article belongs to the Special Issue Advances in the Diagnostics and Therapies of Glioma)
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