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Diagnostics
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Research Update on Contrast-Enhanced Ultrasound
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Research Update on Contrast-Enhanced Ultrasound

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 2614

Special Issue Editor

Prof. Dr. Yi Dong

E-Mail Website
Guest Editor
Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
Interests: liver tumors; pancreatic tumors; contrast enhanced ultrasound; radiological imaging; machine learning; radiomics; diagnosis; prediction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As a non-invasive and real-time medical imaging method, contrast-enhanced ultrasound (CEUS) is increasingly being used in clinical practice. CEUS is an effective imaging method to provide early and accurate diagnoses of various diseases in clinical decision-making and treatment. With time intensity curves and quantitative parameters, dynamic contrast-enhanced ultrasound (DCE-US) is helpful to accurately diagnose some small tumors and quantitatively evaluate their early treatment response. With the development of AI technology and machine learning algorithms, various models could be built based on CEUS features with the aim of diagnosing tumors early and making predictions. Up-to-date research on ultrasound contrast agents or microbubbles is also a potential research hotspot in the future.

Prof. Dr. Yi Dong
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • contrast-enhanced ultrasound
  • diagnosis
  • treatment
  • prediction
  • microbubbles

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Published Papers (2 papers)

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Research

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15 pages, 2815 KiB  
Article
Application of Dynamic Contrast-Enhanced Ultrasound in Evaluation the Activity of Crohn’s Disease
by Ying Wang, Li Wei, Wen-Song Ge, You-Rong Duan, Wen-Jun Ding, Xiu-Yun Lu, Yun-Lin Huang, Sheng Chen, Yi Dong and Peng Du
Diagnostics 2024, 14(7), 672; https://doi.org/10.3390/diagnostics14070672 - 22 Mar 2024
Cited by 2 | Viewed by 1319
Abstract
Background and Objective: The dynamic assessment of disease activity during the follow-up of patients with Crohn’s disease (CD) remains a significant challenge. In this study, we aimed to identify the role of dynamic contrast-enhanced ultrasound (DCE-US) in the evaluation of activity of CD. [...] Read more.
Background and Objective: The dynamic assessment of disease activity during the follow-up of patients with Crohn’s disease (CD) remains a significant challenge. In this study, we aimed to identify the role of dynamic contrast-enhanced ultrasound (DCE-US) in the evaluation of activity of CD. Methods: In the retrospective study, patients diagnosed with CD in our hospital were included. All the diagnoses were confirmed by clinical symptoms and ileocolonoscopical results. All patients underwent intestinal ultrasound and contrast-enhanced ultrasound (CEUS) examinations within 1 week of the ileocolonoscopy examinations. Acuson Sequoia (Siemens Healthineers, Mountain View, CA, USA) and Resona R9 Elite (Mindray Medical Systems, China) with curved array and Line array transducers were used. The CEUS examination was performed with SonoVue (Bracco SpA, Milan, Italy). DCE-US analysis was performed by UltraOffice (version: 0.3-2010, Mindray Medical Systems, China) software. Two regions of interest (ROIs) were set in the anterior section of the infected bowel wall and its surrounding normal bowel wall 2 cm distant from the inflamed area. Time–intensity curves (TICs) were generated and quantitative perfusion parameters were obtained after curve fittings. The Simple Endoscopic Score for Crohn’s disease (SES-CD) was regarded as the reference standard to evaluate the activity of CD. The receiver operating characteristic curve (ROC) analyses were used to determine the diagnostic efficiency of DCE-US quantitative parameters. Results: From March 2023 to November 2023, 52 CD patients were included. According to SES-CD score, all patients were divided into active group with the SES-CD score > 5 (n = 39) and inactive group SES-CD score < 5 (n = 13). Most of the active CD patients showed bowel wall thickness (BWT) > 4.2 mm (97.4%, 38/39) or mesenteric fat hypertrophy (MFH) on intestinal ultrasound (US) scan (69.2%, 27/39). Color Doppler signal of the bowel wall mostly showed spotty or short striped blood flow signal in active CD patients (56.4%, 22/39). According to CEUS enhancement patterns, most active CD patients showed a complete hyperenhancement of the entire intestinal wall (61.5%, 24/39). The TICs of active CD showed an earlier enhancement, higher peak intensity, and faster decline. Among all CEUS quantitative parameters, amplitude-derived parameters peak enhancement (PE), wash-in area under the curve (WiAUC), wash-in rate (WiR), wash-in perfusion index (WiPI), and wash-out rate (WoR) were significantly higher in active CD than in inactive CD (p < 0.05). The combined AUROC of intestinal ultrasound features and DCE-US quantitative perfusion parameters in the diagnosis of active CD was 0.987, with 97.4% sensitivity, 100% specificity, and 98.1% accuracy. Conclusions: DCE-US with quantitative perfusion parameters is a potential useful noninvasive imaging method to evaluate the activity of Crohn’s disease. Full article
(This article belongs to the Special Issue Research Update on Contrast-Enhanced Ultrasound)
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Review

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19 pages, 1846 KiB  
Review
Intracavitary Applications for CEUS in PTCD
by Evelina G. Atanasova, Christo P. Pentchev and Christian P. Nolsøe
Diagnostics 2024, 14(13), 1400; https://doi.org/10.3390/diagnostics14131400 - 30 Jun 2024
Viewed by 971
Abstract
Intracavitary contrast-enhanced ultrasound is widely accepted as a highly informative, safe, and easily reproducible technique for the diagnosis, treatment, and follow-up of different pathologies of the biliary tree. This review article describes the diverse applications for CEUS in intracavitary biliary scenarios, supported by [...] Read more.
Intracavitary contrast-enhanced ultrasound is widely accepted as a highly informative, safe, and easily reproducible technique for the diagnosis, treatment, and follow-up of different pathologies of the biliary tree. This review article describes the diverse applications for CEUS in intracavitary biliary scenarios, supported by a literature review of the utilization of the method in indications like biliary obstruction by various etiologies, including postoperative strictures, evaluation of the biliary tree of liver donors, and evaluation of the localization of a drainage catheter. We also provide pictorial examples of the authors’ personal experience with the use of intracavitary CEUS in cases of PTCD as a palliative intervention. Intracavitary CEUS brings all the positive features of US together with the virtues of contrast-enhanced imaging, providing comparable accuracy to the standard techniques for diagnosing biliary tree diseases. Full article
(This article belongs to the Special Issue Research Update on Contrast-Enhanced Ultrasound)
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