Advanced Neuroimaging Approaches for Brain Lesion

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 3009

Special Issue Editor


E-Mail Website
Guest Editor
1. Department of Radiology and Nuclear Medicine, Esbjerg Hospital—University Hospital of Southern Denmark, Esbjerg, Denmark
2. Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark
3. IRIS—Imaging Research Initiative Southwest, Esbjerg, Denmark
Interests: radiology; neuroimaging; multiple sclerosis; neurological disorders; neurodegeneration; neurological diseases; stroke

Special Issue Information

Dear Colleagues,

Advanced neuroimaging approaches are being used as valuable additional tools in characterizing brain lesions along with conventional imaging techniques. The importance of advanced neuroimaging approaches is that they can provide information regarding the underlying pathophysiology of various brain lesions. Nowadays, both computed tomography (CT) and magnetic resonance imaging (MRI) include modern neuroimaging techniques, like dual-energy CT and photon-counting CT, or perfusion MRI, functional MRI, diffusion-weighted MRI and diffusion tensor imaging, MRI spectroscopy, and MRI fingerprinting. Advanced approaches like radiomics analysis applied to CT and MRI images are increasingly being used for brain lesion characterization. Combining advanced neuroimaging approaches along with artificial intelligence techniques such as machine learning and deep learning algorithms will further promote and accelerate the adaptation of advanced neuroimaging methods in routine clinical neuroimaging. This Special Issue titled "Advanced Neuroimaging Approaches for Brain Lesion" will include the application of advanced neuroimaging approaches for characterization of brain lesions (tumors, demyelinating changes, ischemic stroke, hemorrhage, and infectious lesions) and neurodegenerative disorders, as well as monitoring of treatment-induced brain lesions.

Dr. Ronald Antulov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • advanced neuroimaging
  • dual-energy CT
  • photon-counting CT
  • perfusion MRI
  • MRI fingerprinting
  • brain lesions
  • neurodegenerative disorders
  • treatment-induced brain lesions

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

11 pages, 560 KiB  
Article
Inferior Frontal Sulcal Hyperintensities on Brain MRI Are Associated with Amyloid Positivity beyond Age—Results from the Multicentre Observational DELCODE Study
by Marc Dörner, Katharina Seebach, Michael T. Heneka, Inga Menze, Roland von Känel, Sebastian Euler, Frank Schreiber, Philipp Arndt, Katja Neumann, Annkatrin Hildebrand, Anna-Charlotte John, Anthony Tyndall, Johannes Kirchebner, Pawel Tacik, Robin Jansen, Alexander Grimm, Solveig Henneicke, Valentina Perosa, Sven G. Meuth, Oliver Peters, Julian Hellmann-Regen, Lukas Preis, Josef Priller, Eike Jakob Spruth, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Frank Jessen, Ayda Rostamzadeh, Wenzel Glanz, Jan Ben Schulze, Sarah Lavinia Florence Schiebler, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy-Kluth, Michael Wagner, Ingo Frommann, Falk Lüsebrink, Peter Dechent, Stefan Hetzer, Klaus Scheffler, Luca Kleineidam, Melina Stark, Matthias Schmid, Ersin Ersözlü, Frederic Brosseron, Michael Ewers, Björn H. Schott, Emrah Düzel, Gabriel Ziegler, Hendrik Mattern, Stefanie Schreiber and Jose Bernaladd Show full author list remove Hide full author list
Diagnostics 2024, 14(9), 940; https://doi.org/10.3390/diagnostics14090940 - 30 Apr 2024
Viewed by 1960
Abstract
Inferior frontal sulcal hyperintensities (IFSHs) on fluid-attenuated inversion recovery (FLAIR) sequences have been proposed to be indicative of glymphatic dysfunction. Replication studies in large and diverse samples are nonetheless needed to confirm them as an imaging biomarker. We investigated whether IFSHs were tied [...] Read more.
Inferior frontal sulcal hyperintensities (IFSHs) on fluid-attenuated inversion recovery (FLAIR) sequences have been proposed to be indicative of glymphatic dysfunction. Replication studies in large and diverse samples are nonetheless needed to confirm them as an imaging biomarker. We investigated whether IFSHs were tied to Alzheimer’s disease (AD) pathology and cognitive performance. We used data from 361 participants along the AD continuum, who were enrolled in the multicentre DELCODE study. The IFSHs were rated visually based on FLAIR magnetic resonance imaging. We performed ordinal regression to examine the relationship between the IFSHs and cerebrospinal fluid-derived amyloid positivity and tau positivity (Aβ42/40 ratio ≤ 0.08; pTau181 ≥ 73.65 pg/mL) and linear regression to examine the relationship between cognitive performance (i.e., Mini-Mental State Examination and global cognitive and domain-specific performance) and the IFSHs. We controlled the models for age, sex, years of education, and history of hypertension. The IFSH scores were higher in those participants with amyloid positivity (OR: 1.95, 95% CI: 1.05–3.59) but not tau positivity (OR: 1.12, 95% CI: 0.57–2.18). The IFSH scores were higher in older participants (OR: 1.05, 95% CI: 1.00–1.10) and lower in males compared to females (OR: 0.44, 95% CI: 0.26–0.76). We did not find sufficient evidence linking the IFSH scores with cognitive performance after correcting for demographics and AD biomarker positivity. IFSHs may reflect the aberrant accumulation of amyloid β beyond age. Full article
(This article belongs to the Special Issue Advanced Neuroimaging Approaches for Brain Lesion)
Show Figures

Figure 1

Review

Jump to: Research

25 pages, 139608 KiB  
Review
Neuroimaging in Nonsyndromic Craniosynostosis: Key Concepts to Unlock Innovation
by Camilla Russo, Ferdinando Aliberti, Ursula Pia Ferrara, Carmela Russo, Domenico Vincenzo De Gennaro, Adriana Cristofano, Anna Nastro, Domenico Cicala, Pietro Spennato, Mario Quarantelli, Marco Aiello, Andrea Soricelli, Giovanni Smaldone, Nicola Onorini, Lucia De Martino, Stefania Picariello, Stefano Parlato, Peppino Mirabelli, Lucia Quaglietta, Eugenio Maria Covelli and Giuseppe Cinalliadd Show full author list remove Hide full author list
Diagnostics 2024, 14(17), 1842; https://doi.org/10.3390/diagnostics14171842 - 23 Aug 2024
Viewed by 624
Abstract
Craniosynostoses (CRS) are caused by the premature fusion of one or more cranial sutures, with isolated nonsyndromic CRS accounting for most of the clinical manifestations. Such premature suture fusion impacts both skull and brain morphology and involves regions far beyond the immediate area [...] Read more.
Craniosynostoses (CRS) are caused by the premature fusion of one or more cranial sutures, with isolated nonsyndromic CRS accounting for most of the clinical manifestations. Such premature suture fusion impacts both skull and brain morphology and involves regions far beyond the immediate area of fusion. The combined use of different neuroimaging tools allows for an accurate depiction of the most prominent clinical–radiological features in nonsyndromic CRS but can also contribute to a deeper investigation of more subtle alterations in the underlying nervous tissue organization that may impact normal brain development. This review paper aims to provide a comprehensive framework for a better understanding of the present and future potential applications of neuroimaging techniques for evaluating nonsyndromic CRS, highlighting strategies for optimizing their use in clinical practice and offering an overview of the most relevant technological advancements in terms of diagnostic performance, radiation exposure, and cost-effectiveness. Full article
(This article belongs to the Special Issue Advanced Neuroimaging Approaches for Brain Lesion)
Show Figures

Figure 1

Back to TopTop