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Diagnostics
Special Issues
Diagnosis and Treatment of Meningioma
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Diagnosis and Treatment of Meningioma

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 3156

Special Issue Editors

Dr. Walid Ibn Essayed

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Guest Editor
Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Interests: skull base; brain tumor; tractography; diffusion; image guided surgery; meningioma; chordoma
Dr. Paulo Kadri

E-Mail Website
Guest Editor
Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Interests: neurosurgical procedures; aneurysm; microneurosurgery; glioma; neuro-oncology; endoscopic neurosurgery; neuroanatomy; astrocytoma; brain tumors; Glioblastoma Multiforme (GBM)

Special Issue Information

Dear Colleagues,

Meningiomas are the most common type of primary central nervous system tumors, accounting for around 30% of all intracranial tumors. The management of meningiomas led the way for the development of modern neurosurgery, with surgical treatment at its center. Most meningiomas are benign, with surgery providing curative treatment; however, higher-grade lesions remain relatively frequent (10%), with specific criteria defining atypical and anaplastic lesions, regardless of the subtypes, according to the most recent WHO classification. A better understanding of meningioma genetics and biology will likely lead to a combined histological and molecular classification. Regardless of the grade, radical resection is the first step to avoid recurrences. The surgical approach is tailored to the specific location of the meningioma and the surrounding anatomy. The development of new neuro-radiological and intraoperative navigation tools allowed a better understanding of local anatomy and enhanced surgical planning, leading to better surgical outcomes. Modern radiation therapy techniques are helpful in high-grade and recurrent non-operative meningiomas, with brachytherapy taking an increasing role in the management of recurrent, previously radiated higher-grade meningiomas. Limited medical therapies are available for meningiomas, with multiple medical approaches currently under investigation.

This Special Issue will examine innovative approaches to the understanding, diagnosis, and treatment of meningiomas. Topics include, but are not limited to, the following:

  • Recent advances in meningioma diagnosis and grading;
  • New understanding of meningioma biology and genetics;
  • Place of modern imaging and technological tools in meningioma management;
  • Surgical management of meningiomas;
  • New therapeutic approaches to meningiomas, including brachytherapy, immunotherapy, and future directions;
  • Meningioma in the era of precision medicine.

Dr. Walid Ibn Essayed
Dr. Paulo Kadri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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15 pages, 3317 KiB  
Article
Optic Nerve Sheath Meningiomas: Solving Diagnostic Challenges with 68Ga-DOTATOC PET/CT
by Tatiana Horowitz, Betty Salgues, Laetitia Padovani, Kaissar Farah, Henry Dufour, Olivier Chinot, Eric Guedj and Thomas Graillon
Diagnostics 2023, 13(13), 2307; https://doi.org/10.3390/diagnostics13132307 - 7 Jul 2023
Cited by 1 | Viewed by 1617
Abstract
68Ga-DOTATOC PET could be a noninvasive, highly sensitive, and specific technique for the challenging diagnosis of optic nerve sheath meningioma (ONSM). Our objective was to report the use and results of 68Ga-DOTATOC PET in suspected ONSM. Twelve subjects who underwent 68 [...] Read more.
68Ga-DOTATOC PET could be a noninvasive, highly sensitive, and specific technique for the challenging diagnosis of optic nerve sheath meningioma (ONSM). Our objective was to report the use and results of 68Ga-DOTATOC PET in suspected ONSM. Twelve subjects who underwent 68Ga-DOTATOC PET for suspected ONSM in our department were retrospectively included. Standardised clinical and radiological data were collected. The PET examination results were classified as positive or negative, and lesion standardised uptake values (SUVmax) were recorded. 68Ga-DOTATOC PET confirmed positive uptake in six cases (SUVmax > 5), leading to ONSM diagnoses followed by radiation therapy in patients with vision loss. Six 68Ga-DOTATOC PET scans were considered negative (SUVmax < 5); these comprised one case of neurosarcoidosis, one cavernous malformation, and four uncertain diagnoses, leading to further investigation. 68Ga-DOTATOC PET was helpful in tumour volume delineation before radiation therapy, leading to a decrease in dose exposure. Noninvasive 68Ga-DOTATOC PET should be performed before treating nonhistologically proven meningiomas with radiotherapy or stereotactic radiosurgery, particularly in cases of uncertain diagnosis with MRI, which characterises most ONSM cases. PET SUVmax thresholds to distinguish meningioma from nonspecific uptake in other lesions need to be adapted to ONSM. 68Ga-DOTATOC PET improves the intraorbital lesion diagnostic approach and therefore impacts therapeutic management. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Meningioma)
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13 pages, 2661 KiB  
Systematic Review
Postoperative Seizure Prophylaxis in Meningioma Resection: A Systematic Review and Meta-Analysis
by Sávio Batista, Raphael Bertani, Lucca B. Palavani, Leonardo de Barros Oliveira, Pedro Borges, Stefan W. Koester and Wellingson Silva Paiva
Diagnostics 2023, 13(22), 3415; https://doi.org/10.3390/diagnostics13223415 - 9 Nov 2023
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Abstract
Background: Seizures in the early postoperative period may impair patient recovery and increase the risk of complications. The aim of this study is to determine whether there is any advantage in postoperative seizure prophylaxis following meningioma resection. Methods: This systematic review was conducted [...] Read more.
Background: Seizures in the early postoperative period may impair patient recovery and increase the risk of complications. The aim of this study is to determine whether there is any advantage in postoperative seizure prophylaxis following meningioma resection. Methods: This systematic review was conducted in accordance with PRISMA guidelines. PUBMED, Web of Science, Embase, Science Direct, and Cochrane were searched for papers until April 2023. Results: Among nine studies, a total of 3249 patients were evaluated, of which 984 patients received antiepileptic drugs (AEDs). No significant difference was observed in the frequency of seizure events between patients who were treated with antiepileptic drugs (AEDs) and those who were not. (RR 1.22, 95% CI 0.66 to 2.40; I2 = 57%). Postoperative seizures occurred in 5% (95% CI: 1% to 9%) within the early time period (<7 days), and 9% (95% CI: 1% to 17%) in the late time period (>7 days), with significant heterogeneity between the studies (I2 = 91% and 97%, respectively). In seizure-naive patients, the rate of postoperative seizures was 2% (95% CI: 0% to 6%) in the early period and increased to 6% (95% CI: 0% to 15%) in the late period. High heterogeneity led to the use of random-effects models in all analyses. Conclusions: The current evidence does not provide sufficient support for the effectiveness of prophylactic AED medications in preventing postoperative seizures in patients undergoing meningioma resection. This underscores the importance of considering diagnostic criteria and conducting individual patient analysis to guide clinical decision-making in this context. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Meningioma)
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