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Diagnostics
Special Issues
Advancements in the Diagnosis and Management of Traumatic Brain Injuries
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Advancements in the Diagnosis and Management of Traumatic Brain Injuries

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1190

Special Issue Editor

Prof. Dr. Rudolph J. Castellani

E-Mail Website
Guest Editor
Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Interests: neuropathology; Alzheimer’s disease; brain injury

Special Issue Information

Dear Colleagues,

This Special Issue invites papers that address traumatic brain injuries in humans, related to civilian, military or sports contexts, including issues surrounding their diagnosis, treatment, neuropathological substrates, neuropsychological manifestations, and potential long-term effects. We will consider submissions of cross-sectional survey studies, large-scale epidemiological studies, post mortem case series, neuropsychological analyses, analyses of therapeutic intervention and rehabilitation, studies on fluid and imaging biomarkers, as well as narrative reviews and studies with negative data.

Prof. Dr. Rudolph J. Castellani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • traumatic brain injury
  • concussion
  • sport-related concussion
  • blast injury, military-related traumatic brain injury
  • civilian traumatic brain injury
  • neuroimaging
  • neuropsychology
  • serum biomarkers
  • cerebrospinal fluid biomarkers
  • rehabilitation
  • neurodegeneration
  • traumatic encephalopathy syndrome
  • chronic traumatic encephalopathy

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

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Research

13 pages, 6776 KiB  
Article
Prediction Value of Initial Serum Levels of SERPINA3 in Intracranial Pressure and Long-Term Neurological Outcomes in Traumatic Brain Injury
by Haoyuan Tan, Jiamian Wang, Fengshi Li, Yidong Peng, Jin Lan, Yuanda Zhang, Dongxu Zhao and Yinghui Bao
Diagnostics 2024, 14(12), 1245; https://doi.org/10.3390/diagnostics14121245 - 13 Jun 2024
Viewed by 842
Abstract
Traumatic brain injury (TBI) is a severe neurological condition characterized by inflammation in the central nervous system. SERPINA3 has garnered attention as a potential biomarker for assessing this inflammation. Our study aimed to explore the predictive value of postoperative serum SERPINA3 levels in [...] Read more.
Traumatic brain injury (TBI) is a severe neurological condition characterized by inflammation in the central nervous system. SERPINA3 has garnered attention as a potential biomarker for assessing this inflammation. Our study aimed to explore the predictive value of postoperative serum SERPINA3 levels in identifying the risk of cerebral edema and its prognostic implications in TBI. This study is a prospective observational study, including 37 patients with TBI who finally met our criteria. The Glasgow Outcome Scale (GOS), Levels of Cognitive Functioning (LCF), Disability Rating Scale (DRS), and Early Rehabilitation Barthel Index (ERBI) scores at six months after trauma were defined as the main study endpoint. We further calculated the ventricle-to-intracranial-volume ratio (VBR) at 6 months from CT scans. The study included patients with Glasgow Coma Scale (GCS) scores ranging from 3 to 8, who were subsequently categorized into two groups: the critical TBI group (GCS 3–5 points) and the severe TBI group (GCS 6–8 points). Within the critical TBI group, SERPINA3 levels were notably lower. However, among patients with elevated SERPINA3 levels, both the peak intracranial pressure (ICP) and average mannitol consumption were significantly reduced compared with those of patients with lower SERPINA3 levels. In terms of the 6-month outcomes measured via the GOS, LCF, DRS, and ERBI, lower levels of SERPINA3 were indicative of poorer prognosis. Furthermore, we found a negative correlation between serum SERPINA3 levels and the VBR. The receiver operating characteristic (ROC) curve and decision curve analysis (DCA) demonstrated the predictive performance of SERPINA3. In conclusion, incorporating the novel biomarker SERPINA3 alongside traditional assessment tools offers neurosurgeons an effective and easily accessible means, which is readily accessible early on, to predict the risk of intracranial pressure elevation and long-term prognosis in TBI patients. Full article
(This article belongs to the Special Issue Advancements in the Diagnosis and Management of Traumatic Brain Injuries)
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