Physics and Applications of Microfluidics

A special issue of Fluids (ISSN 2311-5521).

Deadline for manuscript submissions: 30 September 2024 | Viewed by 612

Special Issue Editor


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Guest Editor
Departamento de Engenharia Mecatrónica, Escola de Ciências e Tecnologia, Universidade de Évora, 7000-671 Évora, Portugal
Interests: microfluidics; rarefied gases; porous media flows; biological flows; lattice Boltzmann methods

Special Issue Information

Dear Colleagues,

Research on microfluidics concerns the study of geometrically constrained fluid flows inside domains of micrometric size.

Ever since its introduction, about 40 years ago, the miniaturization of typical fluidic elements, such as channels, reservoirs, or mixing/separation chambers, has attracted significant interest, enabling improvement in the performance of classical devices, such as compact heat exchangers, or the development of innovative concepts, such as the biochip.

However, despite its many technological advantages, the scale reduction in transport phenomena has also introduced new challenges to the physical understanding of the underlying fluid flow mechanisms. Unexpected traits range from the increased prominence of surface-based phenomena, such as capillarity effects in the case of liquids, to the complete breakdown of the classical macroscopic hydrodynamic models in the case of gases. This Special Issue seeks contributions that bring new insight into the physics of microfluidic flows. In this context, theoretical, experimental, and computational approaches are all welcome.

Dr. Goncalo Silva
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fluids is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidics
  • multiphase flow
  • rarefied flow
  • nonequilibrium gas flow
  • biochip
  • lab-on-a-chip
  • microchannels
  • computational fluid dynamics
  • experimental fluid dynamics

Published Papers (1 paper)

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Research

24 pages, 2345 KiB  
Article
Simulation on the Separation of Breast Cancer Cells within a Dual-Patterned End Microfluidic Device
by Diganta Dutta, Xavier Palmer, Jung Yul Lim and Surabhi Chandra
Fluids 2024, 9(6), 123; https://doi.org/10.3390/fluids9060123 (registering DOI) - 25 May 2024
Viewed by 126
Abstract
Microfluidic devices have long been useful for both the modeling and diagnostics of numerous diseases. In the past 20 years, they have been increasingly adopted for helping to study those in the family of breast cancer through characterizing breast cancer cells and advancing [...] Read more.
Microfluidic devices have long been useful for both the modeling and diagnostics of numerous diseases. In the past 20 years, they have been increasingly adopted for helping to study those in the family of breast cancer through characterizing breast cancer cells and advancing treatment research in portable and replicable formats. This paper adds to the body of work concerning cancer-focused microfluidics by proposing a simulation of a hypothetical bi-ended three-pronged device with a single channel and 16 electrodes with 8 pairs under different voltage and frequency regimes using COMSOL. Further, a study was conducted to examine the frequencies most effective for ACEO to separate cancer cells and accompanying particles. The study revealed that the frequency of EF has a more significant impact on the separation of particles than the inlet velocity. Inlet velocity variations while holding the frequency of EF constant resulted in a consistent trend showing a direct proportionality between inlet velocity and net velocity. These findings suggest that optimizing the frequency of EF could lead to more effective particle separation and targeted therapeutic interventions for breast cancer. This study hopefully will help to create targeted therapeutic interventions by bridging the disparity between in vitro and in vivo models. Full article
(This article belongs to the Special Issue Physics and Applications of Microfluidics)
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