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Gels
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Drug-Loaded Hydrogel Biomaterials
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Drug-Loaded Hydrogel Biomaterials

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 11994

Special Issue Editors

Dr. Hua-Jie Wang

E-Mail Website
Guest Editor
R&D Center of 3D Bioprinting and New Materials, School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang 453003, China
Interests: 3D/bioprinting; biomaterials; tissue engineering
Dr. Ali Raza

E-Mail Website
Guest Editor
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
Interests: drug-delivery systems; 3D/bioprinting; biomaterials; tissue engineering; gel-based biomaterials; hemostatic materials
Dr. Damien Dupin

E-Mail Website
Guest Editor
CIDETEC Parque Científico y Tecnológico de Gipuzkoa Pº Miramón, 196, 20014 Donostia-San Sebastian, Spain
Interests: dynamic hydrogels; stimuli-responsive materials; colloids; emulsions; biomaterials; tissue engineering; wound healing; drug delivery; rheology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hydrogels have been widely explored as a biomaterial due to their biocompatibility, water content, and structural similarity with the extracellular matrix. Additionally, they can carry the active molecules to support tissue growth. Recently, injectable hydrogels have gained significant attention due to their minimal invasiveness, easy handling, and deep tissue penetration. This Special Issue is dedicated to recent developments in synthetic- and natural-material hydrogels as biomaterials with the ability to deliver the encapsulated drug.

This Special Issue will cover all aspects of the subject area, including the preparation of novel hydrogels, solution of existing problems such as improvement in mechanical properties, biocompatibility study, in situ crosslinking strategies, and in-depth clinical study of existing systems for clinical translation. We warmly welcome researchers working on stimuli-responsive hydrogels as biomaterials with the ability to release the on-demand drug in response to external/internal stimuli to improve tissue regeneration. This Special Issue will comprise original research articles as well as comprehensive reviews, communications, and perspectives, and will provide a platform to guide the future direction in the subject matter.

Dr. Hua-Jie Wang
Dr. Ali Raza
Dr. Damien Dupin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogels
  • drug delivery
  • controlled release
  • biomaterial
  • tissue engineering
  • stimuli-responsive hydrogel
  • polymeric hydrogels
  • injectable hydrogels
  • bioprinting

Published Papers (6 papers)

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Research

15 pages, 3182 KiB  
Article
Chitosan Hydrogel-Delivered ABE8e Corrects PAX9 Mutant in Dental Pulp Stem Cells
by Bowen Liu, Chenjiao Zhang, Han Zhao, Jian Gao and Jingchao Hu
Gels 2023, 9(6), 436; https://doi.org/10.3390/gels9060436 - 25 May 2023
Viewed by 1327
Abstract
Hypodontia (dental agenesis) is a genetic disorder, and it has been identified that the mutation C175T in PAX9 could lead to hypodontia. Cas9 nickase (nCas9)-mediated homology-directed repair (HDR) and base editing were used for the correction of this mutated point. This study aimed [...] Read more.
Hypodontia (dental agenesis) is a genetic disorder, and it has been identified that the mutation C175T in PAX9 could lead to hypodontia. Cas9 nickase (nCas9)-mediated homology-directed repair (HDR) and base editing were used for the correction of this mutated point. This study aimed to investigate the effect of HDR and the base editor ABE8e in editing PAX9 mutant. It was found that the chitosan hydrogel was efficient in delivering naked DNA into dental pulp stem cells (DPSCs). To explore the influence of the C175T mutation in PAX9 on the proliferation of DPSCs, hydrogel was employed to deliver PAX9 mutant vector into DPSCs, finding that the PAX9-containing C175T mutation failed to promote the proliferation of DPSCs. Firstly, DPSCs stably carrying PAX9 mutant were constructed. Either an HDR or ABE8e system was delivered into the above-mentioned stable DPSCs, and then the correction efficiency using Sanger sequencing and Western blotting was determined. Meanwhile, the ABE8e presented significantly higher efficiency in correcting C175T compared with HDR. Furthermore, the corrected PAX9 presented enhanced viability and differentiation capacity for osteogenic and neurogenic lineages; the corrected PAX9 even possessed extremely enhanced transcriptional activation ability. In summary, this study has powerful implications for studies into base editors, chitosan hydrogel, and DPSCs in treating hypodontia. Full article
(This article belongs to the Special Issue Drug-Loaded Hydrogel Biomaterials)
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12 pages, 3294 KiB  
Article
Synthesis of Cationic Quaternized Nanolevan Derivative for Small Molecule and Nucleic Acid Delivery
by Chonnipha Charoenwongphaibun, Chanchao Lorthongpanich, Prapasri Septham, Karan Wangpaiboon, Pawinee Panpetch, Rath Pichyangkura, Thanapon Charoenwongpaiboon and Kamontip Kuttiyawong
Gels 2023, 9(3), 188; https://doi.org/10.3390/gels9030188 - 28 Feb 2023
Viewed by 1756
Abstract
Levan is a biopolymer composed of fructose chains covalently linked by β−2,6 glycosidic linkages. This polymer self−assembles into a nanoparticle of uniform size, making it useful for a wide range of applications. Also, levan exhibits various biological activities such as antioxidants, anti-inflammatory, and [...] Read more.
Levan is a biopolymer composed of fructose chains covalently linked by β−2,6 glycosidic linkages. This polymer self−assembles into a nanoparticle of uniform size, making it useful for a wide range of applications. Also, levan exhibits various biological activities such as antioxidants, anti-inflammatory, and anti-tumor, that make this polymer very attractive for biomedical application. In this study, levan synthesized from Erwinia tasmaniensis was chemically modified by glycidyl trimethylammonium chloride (GTMAC) to produce cationized nanolevan (QA-levan). The structure of the obtained GTMAC−modified levan was determined by FT-IR, 1H-NMR and elemental (CHN) analyzer. The size of the nanoparticle was calculated using the dynamic light scattering method (DLS). The formation of DNA/QA-levan polyplex was then investigated by gel electrophoresis. The modified levan was able to increase the solubility of quercetin and curcumin by 11-folds and 205-folds, respectively, compared to free compounds. Cytotoxicity of levan and QA−levan was also investigated in HEK293 cells. This finding suggests that GTMAC−modified levan should have a potential application for drug and nucleic acid delivery. Full article
(This article belongs to the Special Issue Drug-Loaded Hydrogel Biomaterials)
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21 pages, 3115 KiB  
Article
Potential Hemostatic and Wound Healing Effects of Thermoresponsive Wound Dressing Gel Loaded with Lignosus rhinocerotis and Punica granatum Extracts
by Farha Yasmin Faris Taufeq, Nur Hamizah Habideen, Loageshwari Nagaswa Rao, Promit Kumar Podder and Haliza Katas
Gels 2023, 9(1), 48; https://doi.org/10.3390/gels9010048 - 06 Jan 2023
Cited by 3 | Viewed by 2024
Abstract
Biologically active compounds in Lignosus rhinocerotis and Punica granatum are found to facilitate wound healing and exhibit hemostatic activity, making them a good combination as bioactives for wound dressings. This study, therefore, aimed to evaluate the potential of thermoresponsive gels loaded with L. [...] Read more.
Biologically active compounds in Lignosus rhinocerotis and Punica granatum are found to facilitate wound healing and exhibit hemostatic activity, making them a good combination as bioactives for wound dressings. This study, therefore, aimed to evaluate the potential of thermoresponsive gels loaded with L. rhinocerotis (HLRE) and P. granatum (PPE) extracts as dressings for wound treatment. The gels were prepared using Pluronic PF127 polymer and mixed with PEG 400 and/or starch prior to incorporation with both extracts (0.06 to 1 mg/mL). The gelation temperature (Tgel) at the skin temperature was achieved when Pluronic PF127 was mixed with 22% w/v PEG 400 and reduced to 25.7 ± 0.3–26.7 ± 1.2 °C after adding HLRE and PPE. The gels exhibited satisfactory hardness (2.02 ± 0.19–6.45 ± 0.53 N), cohesiveness (0.9 ± 0.07–2.28 ± 0.4 mJ), adhesiveness (5.07 ± 2.41–19.6 ± 1.1 mJ), and viscosity (0.15 ± 0.04–0.95 ± 0.03 Pa.s), suitable for wound dressings. The optimized gels displayed high thrombin activity and cell migration rate (wound closure of 74% ± 12–89% ± 2 within 24 h), demonstrating hemostatic and healing effects. The thermoresponsive gels demonstrated advantages to be used as dressings for treating acute and open wounds. Full article
(This article belongs to the Special Issue Drug-Loaded Hydrogel Biomaterials)
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20 pages, 6624 KiB  
Article
Design and Evaluation of Solid Lipid Nanoparticles Loaded Topical Gels: Repurpose of Fluoxetine in Diabetic Wound Healing
by Farhat Fatima, Mohammad Aleemuddin, Mohammed Muqtader Ahmed, Md. Khalid Anwer, Mohammed F. Aldawsari, Gamal A. Soliman, Wael A. Mahdi, Mohammed Jafar, Abubaker M. Hamad and Sultan Alshehri
Gels 2023, 9(1), 21; https://doi.org/10.3390/gels9010021 - 27 Dec 2022
Cited by 11 | Viewed by 2343
Abstract
The current study aimed to prepare a topical gel containing solid lipid nanoparticles (SLNs) encapsulating fluoxetine for diabetic wound healing effects. Fluoxetine (FX) was loaded into SLNs by employing an emulsion solvent evaporation technique using stearic acid as a lipid, and soya lecithin [...] Read more.
The current study aimed to prepare a topical gel containing solid lipid nanoparticles (SLNs) encapsulating fluoxetine for diabetic wound healing effects. Fluoxetine (FX) was loaded into SLNs by employing an emulsion solvent evaporation technique using stearic acid as a lipid, and soya lecithin as a surfactant. SLNs were then evaluated for particle size, polydispersity index (PDI), zeta potential (ZP), percent entrapment efficiency (%EE), percent drug loading (%DL), and in vitro drug release. The optimized SLN (FS3) composed of FX (100 mg), SA (150 mg), and SA (100 mg) displayed mean particle size (467.3 ± 2.2nm), PDI (0.435 ± 0.02), ZP (−32.2 ± 4.47mV), EE (95.8 ± 3.38%), and DL (16.4 ± 2.4%). FTIR and DSC studies denote drug-polymer compatibility and the amorphous nature of FX in the SLNs. The drug release at 24 h was found to be (98.89 ± 2.57%) which followed the fickian diffusion mechanism. SLN (FS3) was further loaded into carbopol gel and tested for pH, spreadability, and extrudability of pharmaceutical parameters. In-vitro release of FX from the SLN gel and plain gel was compared, diabetic wound healing gel (DWH) showed sustained drug delivery. An in vivo study was also performed for DWH gel in streptozotocin-induced diabetic rats. Histopathological examination exhibited DWH gel-treated wounds have increased hydroxyproline, cellular proliferation, a rise in the number of blood vessels, and the level of collagen synthesis. Thus, DWH gel-loaded SLN encapsulated with FX could be a potential carrier for the effective treatment and management of diabetic wounds. Full article
(This article belongs to the Special Issue Drug-Loaded Hydrogel Biomaterials)
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19 pages, 3571 KiB  
Article
Development of Thermoresponsive-Gel-Matrix-Embedded Amoxicillin Trihydrate-Loaded Bovine Serum Albumin Nanoparticles for Local Intranasal Therapy
by Sandra Aulia Mardikasari, Mária Budai-Szűcs, László Orosz, Katalin Burián, Ildikó Csóka and Gábor Katona
Gels 2022, 8(11), 750; https://doi.org/10.3390/gels8110750 - 19 Nov 2022
Cited by 6 | Viewed by 1835
Abstract
A high dose of amoxicillin is recommended as the first-line therapy for acute bacterial rhinosinusitis (ABR). However, oral administration of amoxicillin is connected to many adverse reactions coupled with moderate bioavailability (~60%). Therefore, this study aimed to develop a topical nasal preparation of [...] Read more.
A high dose of amoxicillin is recommended as the first-line therapy for acute bacterial rhinosinusitis (ABR). However, oral administration of amoxicillin is connected to many adverse reactions coupled with moderate bioavailability (~60%). Therefore, this study aimed to develop a topical nasal preparation of amoxicillin, employing a thermoresponsive nanogel system to increase nasal residence time and prolong drug release. Rheological investigations revealed that formulations containing 21–23% w/w Poloxamer 407 (P407) were in accordance with the requirement of nasal administration (gelling temperature ~35 °C). The average hydrodynamic diameter (<200 nm), pH (6.7–6.9), and hypertonic osmolality (611–663 mOsmol/L) of the in situ gelling nasal nanogel appeared as suitable characteristics for local rhinosinusitis treatment. Moreover, taking into account the mucoadhesive strength and drug release studies, the 21% w/w P407 could be considered as an optimized concentration for effective nasal delivery. Antibacterial activity studies showed that the ability of amoxicillin-loaded in situ gelling nasal nanogel to inhibit bacterial growth (five common ABR pathogens) preserved its effectiveness in comparison to 1 mg/mL amoxicillin aqueous solution as a positive control. Altogether, the developed amoxicillin-loaded in situ gelling thermoresponsive nasal nanogel can be a potential candidate for local antibiotic therapy in the nasal cavity. Full article
(This article belongs to the Special Issue Drug-Loaded Hydrogel Biomaterials)
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20 pages, 6619 KiB  
Article
Design and Optimization of In Situ Gelling Mucoadhesive Eye Drops Containing Dexamethasone
by Boglárka Szalai, Orsolya Jójárt-Laczkovich, Anita Kovács, Szilvia Berkó, György Tibor Balogh, Gábor Katona and Mária Budai-Szűcs
Gels 2022, 8(9), 561; https://doi.org/10.3390/gels8090561 - 02 Sep 2022
Cited by 6 | Viewed by 1933
Abstract
Poor bioavailability of eye drops is a well-known issue, which can be improved by increasing the residence time on the eye surface and the penetration of the active pharmaceutical ingredient (API). This study aims to formulate in situ gelling mucoadhesive ophthalmic preparations. To [...] Read more.
Poor bioavailability of eye drops is a well-known issue, which can be improved by increasing the residence time on the eye surface and the penetration of the active pharmaceutical ingredient (API). This study aims to formulate in situ gelling mucoadhesive ophthalmic preparations. To increase the residence time, the formulations were based on a thermosensitive polymer (Poloxamer 407 (P407)) and were combined with two types of mucoadhesive polymers. Dexamethasone (DXM) was solubilized by complexation with cyclodextrins (CD). The effect of the composition on the gel structure, mucoadhesion, dissolution, and permeability was investigated with 33 full factorial design. These parameters of the gels were measured by rheological studies, tensile test, dialysis membrane diffusion, and in vitro permeability assay. The dissolution and permeability of the gels were also compared with DXM suspension and CD-DXM solution. The gelation is strongly determined by P407; however, the mucoadhesive polymers also influenced it. Mucoadhesion increased with the polymer concentration. The first phase of drug release was similar to that of the CD-DXM solution, then it became prolonged. The permeability of DXM was significantly improved. The factorial design helped to identify the most important factors, thereby facilitating the formulation of a suitable carrier for the CD-DXM complex. Full article
(This article belongs to the Special Issue Drug-Loaded Hydrogel Biomaterials)
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