New Advances in Neural Therapeutic Application of Mesenchymal Stem Cells
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 840
Special Issue Editors
Interests: adipose-derived stem cells; neural differentiation; conditioned media; Schwann cells; olfactory ensheathing cells
Special Issues, Collections and Topics in MDPI journals
Interests: mesenchymal stem cells; cell differentiation; intercellular communication
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mesenchymal stem cells (MSCs) can differentiate into endodermal and ectodermal cells, including neurons and glial cells. For this reason, MSCs can be suitable for cell-based therapeutic strategies, especially in pathologies where pharmacological treatments give poor results. MSCs may be useful in the case of central nervous system injury (e.g., stroke, spinal cord injury) and irreversible neurological disorders (e.g., Parkinson’s disease, Alzheimer’s disease) characterized by progressive neuronal death, in which behavioral and cognitive functions of patients inexorably decline as the disease progresses.
This Special Issue entitled “New Advances in Neural Therapeutic Application of Mesenchymal Stem Cells” focuses on the possible roles of MSCs for the treatment of disabling neurodegenerative disorders or central nervous system injury.
Mechanisms of MSC-induced beneficial effects include neurogenesis and angiogenesis stimulation and immunomodulatory, anti-inflammatory, and antiapoptotic actions. Moreover, the paracrine release of neurotrophic factors and cytokines, mainly delivered at damaged regions, may help to restore tissue homeostasis.
This Special Issue welcomes bioinformatic analyses, review articles, and original data focusing on the use of MSCs in cell-replacement therapies aimed at restoring disease-disrupted brain circuitry.
Dr. Giuliana Mannino
Dr. Debora Lo Furno
Guest Editors
Manuscript Submission Information
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Keywords
- mesenchymal stem cells
- neural differentiation
- nervous system injury
- neurological diseases
- regenerative medicine
