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The Role of Natural and Synthetic Sulfur Compounds in Human Health and Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 June 2024 | Viewed by 1255

Special Issue Editor

Dr. Eugenia Piragine

E-Mail Website
Guest Editor
Department of Pharmacy, University of Pisa, Pisa, Italy
Interests: cardiovascular pharmacology; gasotransmitters; hydrogen sulfide (H2S); synthetic and natural H2S-donors

Special Issue Information

Dear Colleagues, 

Sulfur metabolism plays a central role in redox biochemistry and tissue homeostasis in humans. Increasing evidence indicates an imbalance in sulfur metabolism in many diseases, from cardiovascular to metabolic disorders. Therefore, the use of sulfur compounds is emerging as a possible therapeutic strategy to restore the balance of sulfur metabolism, preserve human health and slow the progression of disease. Of note, some sulfur compounds can act as hydrogen sulfide (H2S) donors. This is an intriguing aspect of the pharmacology of sulfur compounds. In fact, the gasotransmitter H2S exhibits a plethora of beneficial effects: it enhances the endogenous antioxidant defense system, counteracts the inflammatory process, promotes vasorelaxation, and slows cellular senescence. This Special Issue aims to evaluate the role of sulfur compounds in human health and diseases to support a possible clinical use of natural and synthetic sulfur compounds in the prevention and treatment of multiple pathological conditions.

Dr. Eugenia Piragine
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sulfur compounds
  • sulfur metabolism
  • hydrogen sulfide
  • H2S-donors
  • human health
  • human disease
  • nutraceuticals

Published Papers (1 paper)

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Research

21 pages, 2675 KiB  
Article
The Anticancer Effects of the Garlic Organosulfide Diallyl Trisulfide through the Attenuation of B[a]P-Induced Oxidative Stress, AhR Expression, and DNA Damage in Human Premalignant Breast Epithelial (MCF-10AT1) Cells
by Dominique T. Ferguson, Equar Taka, Syreeta L. Tilghman, Tracy Womble, Bryan V. Redmond, Shasline Gedeon, Hernan Flores-Rozas, Sarah L. Reed, Karam F. A. Soliman, Konan J. W. Kanga and Selina F. Darling-Reed
Int. J. Mol. Sci. 2024, 25(2), 923; https://doi.org/10.3390/ijms25020923 - 11 Jan 2024
Cited by 1 | Viewed by 958
Abstract
Benzo[a]pyrene (B[a]P) is the most characterized polycyclic aromatic hydrocarbon associated with breast cancer. Our lab previously reported that the organosulfur compound (OSC), diallyl trisulfide (DATS), chemoprevention mechanism works through the induction of cell cycle arrest and a reduction in oxidative stress and DNA [...] Read more.
Benzo[a]pyrene (B[a]P) is the most characterized polycyclic aromatic hydrocarbon associated with breast cancer. Our lab previously reported that the organosulfur compound (OSC), diallyl trisulfide (DATS), chemoprevention mechanism works through the induction of cell cycle arrest and a reduction in oxidative stress and DNA damage in normal breast epithelial cells. We hypothesize that DATS will inhibit B[a]P-induced cancer initiation in premalignant breast epithelial (MCF-10AT1) cells. In this study, we evaluated the ability of DATS to attenuate B[a]P-induced neoplastic transformation in MCF-10AT1 cells by measuring biological endpoints such as proliferation, clonogenicity, reactive oxygen species (ROS) formation, and 8-hydroxy-2-deoxyguanosine (8-OHdG) DNA damage levels, as well as DNA repair and antioxidant proteins. The results indicate that B[a]P induced proliferation, clonogenic formation, ROS formation, and 8-OHdG levels, as well as increasing AhR, ARNT/HIF-1β, and CYP1A1 protein expression compared with the control in MCF-10AT1 cells. B[a]P/DATS’s co-treatment (CoTx) inhibited cell proliferation, clonogenic formation, ROS formation, AhR protein expression, and 8-OHdG levels compared with B[a]P alone and attenuated all the above-mentioned B[a]P-induced changes in protein expression, causing a chemopreventive effect. This study demonstrates, for the first time, that DATS prevents premalignant breast cells from undergoing B[a]P-induced neoplastic transformation, thus providing more evidence for its chemopreventive effects in breast cancer. Full article
(This article belongs to the Special Issue The Role of Natural and Synthetic Sulfur Compounds in Human Health and Diseases)
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